Protein Alignment KLHL18 and enc3

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001001402.2
• Gene: enc3 / 327531
• ZFINID: ZDB-GENE-030131-5742
• Length: 589
• Species: Danio rerio
• Alignment Length: 544
• Identity: 159/544 - (29%)
• Similarity: 258/544 - (47%)
• Gaps: 38/544 - (6%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:.....||.|:...:.|..||.|||:...||.|||:..:.|||..|:...:| :.|..||.|:
Zfish    39 LRKRRVFTDVVLRAGHRVFPCHRAVLASCSRYFEAMFSGGLKESRDAEVNFHDS-LHPEVLELLL 102

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            :|.||.:|.|:.:|.::|:.....||..::|||.:.||....||.|.||:...:|:..|::|.:.
Zfish   103 DYAYSARVIINEENAESLLEAGDMLQFHDIRDAASEFLEKNLHPSNCLGMMLLSDAHQCQRLYEL 167

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            :.:....|||.:..:|:||:|..:::.||:..:||.|..|.:::||.:.||:....:|....|.:
Zfish   168 SWRMCLANFANLYHTEDFLSLPKDKVQELVFSEELEVEDESIVYEAVIDWVRADIGRRHLDLPDL 232

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHL-MPERRGLLQSFRTRQRSGEFFT 290
            |..|||.||...:|...||.|||:......|:::::|....: :.:..|::..|..|.|.   .:
Zfish   233 LRCVRLALLPETYLLKNVASEELVMGHKVGREIVEDAVRCKMKILQNDGVVTGFCARPRK---VS 294

  Fly   291 GQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLST 355
            ..:..:||.....:.|..:   |...|:......:...|.......:..|:|..|| .|:|..::
Zfish   295 QALLLLGGQTFMCDKVYMI---DHKAKEITPKTDLPSPRKECSACAIGCKVYVTGG-RGSENGAS 355

  Fly   356 --VEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGV---------TSLNTVEVYYPK 409
              |.|||...::||:...||..|...|.|.||..:||.||:..:         .||..||.|.|:
Zfish   356 KDVWVYDTLHDEWSKAAQMLVARFGHGSAELDHILYVVGGHTSLAGSFPASPSVSLKQVEQYNPQ 420

  Fly   410 SNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSI----FDSVERYDQAEDVWV--KMSPMLN 468
            ||.|..||.:.:..|...|......::|.|   |.|:    :..|:.:|..|:.|.  ...|.|.
Zfish   421 SNKWTLVAPLREGVSNAAVVGAKNKLFAFG---GTSVNRDKYPKVQCFDPCENRWTVPATCPQLW 482

  Fly   469 RRCRLGVATLNGKIYVCGG---YCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLW 530
            |  ....|.:...:.|.||   :..:|..|    ::.:|..|.....:..||......|:..:|:
Zfish   483 R--YTAAAVVGNHVVVIGGDTEFSASSAYR----FNSETFQWTKFGDVTSKRISCHAVASGNRLY 541

  Fly   531 AIGGYDGESNLSTVEVYDPETDKW 554
            .:|||.|.....|::.|||.||.|
Zfish   542 VVGGYFGAQRCKTLDCYDPSTDSW 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	38/104 (37%)
		PHA03098	36..510	CDD:222983	143/494 (29%)
		KELCH repeat	329..372	CDD:276965	13/44 (30%)
		KELCH repeat	376..417	CDD:276965	18/49 (37%)
		KELCH repeat	423..466	CDD:276965	10/48 (21%)
		KELCH repeat	470..514	CDD:276965	8/46 (17%)
		Kelch_1	517..560	CDD:396078	14/38 (37%)
		KELCH repeat	517..560	CDD:276965	14/38 (37%)
enc3	NP_001001402.2	BTB_POZ	6..152	CDD:453885	42/113 (37%)
		PHA03098	60..566	CDD:222983	154/523 (29%)
		BACK_KLHL25_like	145..242	CDD:350539	32/96 (33%)
		KELCH repeat	330..374	CDD:276965	13/44 (30%)
		KELCH repeat	378..431	CDD:276965	20/52 (38%)
		KELCH repeat	434..480	CDD:276965	10/48 (21%)
		KELCH repeat	528..570	CDD:276965	14/38 (37%)