DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl41b

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_945330.1	Gene:	klhl41b / 321064	ZFINID:	ZDB-GENE-030131-9875	Length:	605	Species:	Danio rerio

Alignment Length:	586	Identity:	141/586 - (24%)
Similarity:	247/586 - (42%)	Gaps:	57/586 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KLFGESFPLF---------KEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAES 75
            |...|...||         ||:....|..|.|||:.|:.|..||:::||..|||..:|.:...:.
Zfish     4 KAIKEELRLFQSTLLQDGLKELLNENKFVDCTLKIGDRCFPCHRLIMAACSPYFRELFFSEDGKE 68

  Fly    76 RI--KEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRF 138
            :.  ||:.:.:  ::|:.::.::.|:||.::.:.:.|||.:...|:..|:.:|...|.::|..:.
Zfish    69 KDIGKEVVLDD--VDPNIMDMILQYLYSAEIDLVDDNVQEIFAVANRFQIPSVFTVCVNYLQQKL 131

  Fly   139 HPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEV 203
            ...|.|.:......:...:|..||..:|...|..||..||||.|...:|..|:..|.|||..|||
Zfish   132 SMANCLAVFRLGLVLSVPRLAIAARDFIADRFETVSSEEEFLQLAPHELSALIGGDMLNVEKEEV 196

  Fly   204 IFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLD------- 261
            :||:.||||:..:..|.:...:....:|..||..::..::|..:::|:...:....|.
Zfish   197 VFESVMKWVRNDKANRVKSLAEAFDCIRFRLLPEKYFREKVETDDIIKGDPELLKKLQLVKDAFK 261

  Fly   262 ---------EAKDFHLMPERRG--LLQSF-RTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDP 314
                     |.|:..:..|..|  :|..| ...:|.|.:....|..:...|:....|...|.:
Zfish   262 GKLPKKKPKEKKEGEVNGEEEGEEMLPGFLNDNRRLGMYGRDLIVMINDTAAVAYDVVENECF-- 324

  Fly   315 LTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGF--NGTERLSTVEVY----DPRKNKWSQGCAML 373
               ...|.||:.  ::.|.:.....:|:..||.  :...:.|.::.|    |...:.|.....|.
Zfish   325 ---LAAMAEQVP--KNHVSLCTKKNQLFIVGGLFVDEESKESPLQCYFYQLDSFSSDWRALPPMP 384

  Fly   374 CKRSAVGVAALDDCIYVCGGYDGVT--SLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVY 436
            ..|....:...::.::...|.|..|  ||::|..:..:...|....::..:.....|...|..||
Zfish   385 SPRCLFNLGESENLLFAIAGKDLQTNESLDSVMCFDTERMKWSETKKLPLHIHGHSVVSHNNLVY 449

  Fly   437 ALGGH-DGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECY 500
            .:||. |.......:..|:..:..|.:::.|...|...|.....|||.|.||...:......|.|
Zfish   450 CIGGKTDDNKALSKMFVYNHKQSEWRELASMKTPRAMFGAVVHKGKIIVTGGVNEDGLTALSETY 514

  Fly   501 DPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYD---------GESNLSTVEVYDPETDKWTF 556
            |..|:.|...|....:||.|.|.::.|.|::|||:.         |.|.::.:..|:.:...|:.
Zfish   515 DFDTNKWDTFTEFPQERSSVNLVSSGGNLFSIGGFAIVELEDKNIGPSEITDIWQYEEDKKTWSG 579

  Fly   557 M 557
            |
Zfish   580 M 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	31/116 (27%)
		PHA03098	36..510	CDD:222983	120/503 (24%)
		BACK	143..245	CDD:285009	32/101 (32%)
		Kelch	292..339	CDD:128874	8/46 (17%)
		KELCH repeat	329..372	CDD:276965	8/48 (17%)
		Kelch	340..386	CDD:128874	9/51 (18%)
		KELCH repeat	376..417	CDD:276965	8/42 (19%)
		Kelch	387..433	CDD:128874	8/47 (17%)
		KELCH repeat	423..466	CDD:276965	9/43 (21%)
		Kelch	435..480	CDD:128874	10/45 (22%)
		Kelch_1	469..514	CDD:279660	14/44 (32%)
		KELCH repeat	470..514	CDD:276965	14/43 (33%)
		Kelch_1	517..560	CDD:279660	14/50 (28%)
		KELCH repeat	517..560	CDD:276965	14/50 (28%)
klhl41b	NP_945330.1	BTB	22..128	CDD:279045	30/107 (28%)
		PHA03098	46..528	CDD:222983	114/490 (23%)
		BACK	136..238	CDD:285009	32/101 (32%)
		Kelch 1. /evidence=ECO:0000255	345..397		9/51 (18%)
		KELCH repeat	387..432	CDD:276965	8/44 (18%)
		Kelch 2. /evidence=ECO:0000255	398..446		8/47 (17%)
		KELCH repeat	436..481	CDD:276965	9/44 (20%)
		Kelch_6	437..484	CDD:290672	10/46 (22%)
		Kelch 3. /evidence=ECO:0000255	447..494		10/46 (22%)
		Kelch_1	483..521	CDD:279660	12/37 (32%)
		KELCH repeat	484..529	CDD:276965	14/44 (32%)
		Kelch 4. /evidence=ECO:0000255	496..541		14/44 (32%)
		KELCH repeat	531..578	CDD:276965	12/46 (26%)
		Kelch 5. /evidence=ECO:0000255	543..598		9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810