DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Klhl4

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001101714.1	Gene:	Klhl4 / 317196	RGDID:	1565441	Length:	717	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	228/573 - (39%)
Similarity:	327/573 - (57%)	Gaps:	19/573 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EDQYFVYKH-DKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMA 73
            ||.|....| |....:.....||    .|||||.|........|||:||:|...||.|||||::.
  Rat   155 EDHYRSRNHADYTLCKMESYLKE----KKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVL 215

  Fly    74 ESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRF 138
            |:|.:|:.|:  .::|:||.||:.|.|:|.:::....::||:..|..|||:.|.|.|.:|||.:.
  Rat   216 EARQEEVKME--GVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQL 278

  Fly   139 HPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEV 203
            ||.|.||||:|.|:..|.:|.:.|.||..::|..|.:::|||.|...::.:|:..|::||..||.
  Rat   279 HPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVPDEET 343

  Fly   204 IFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHL 268
            ||.|.|:||.:....|.:...::|:.:||||||||.||| :....:.....:|:.||.||..:||
  Rat   344 IFHALMQWVGHDAQARQQDLAKLLSYIRLPLLSPQLLAD-LENSSMFSGDLECQKLLMEAMKYHL 407

  Fly   269 MPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVG 333
            :||||.:|||.||:.|...  .|.:|||||: ...:..:|:|.||..|..|.....||..|.:.|
  Rat   408 LPERRSMLQSPRTKPRKST--VGALYAVGGM-DAAKGTTTIEKYDLRTNSWIHIGTMSGRRLQFG 469

  Fly   334 VAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVT 398
            |||::.|||..||.:|.:.|:|||.::|....|.....|...|..:|||.|:..:|..||:||.:
  Rat   470 VAVVDNKLYVVGGRDGLKTLNTVECFNPVTKTWVVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS 534

  Fly   399 SLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKM 463
            .|||||.:.|....|..||.|...||..||..||..:||:||.||.|...|:|.:|...:.|...
  Rat   535 YLNTVERWDPDGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 599

  Fly   464 SPMLNRRCRLGVATLNGKIYVCGGY---CGNSFLRSVEC---YDPQTDTWKLVTPMNCKRSRVAL 522
            :||..||..:||||.||.:||.||:   ..|...|..:|   |||::|:|..|.|::..|..||:
  Rat   600 APMSKRRGGVGVATHNGYLYVVGGHDAPAPNHCSRLSDCVERYDPKSDSWSTVAPLSVPRDAVAV 664

  Fly   523 AANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRIE 575
            .....||:.:|||||.:.|:|||.||.:.|:|....|:  :.|..||.|:.::
  Rat   665 CPLGDKLYVVGGYDGHTYLNTVESYDAQKDEWKEEVPV--NIGRAGACVVVVK 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	43/105 (41%)
		PHA03098	36..510	CDD:222983	196/479 (41%)
		BACK	143..245	CDD:285009	42/101 (42%)
		Kelch	292..339	CDD:128874	18/46 (39%)
		KELCH repeat	329..372	CDD:276965	17/42 (40%)
		Kelch	340..386	CDD:128874	18/45 (40%)
		KELCH repeat	376..417	CDD:276965	17/40 (43%)
		Kelch	387..433	CDD:128874	20/45 (44%)
		KELCH repeat	423..466	CDD:276965	17/42 (40%)
		Kelch	435..480	CDD:128874	19/44 (43%)
		Kelch_1	469..514	CDD:279660	22/50 (44%)
		KELCH repeat	470..514	CDD:276965	21/49 (43%)
		Kelch_1	517..560	CDD:279660	18/42 (43%)
		KELCH repeat	517..560	CDD:276965	18/42 (43%)
Klhl4	NP_001101714.1	BTB	171..275	CDD:279045	43/109 (39%)
		PHA03098	175..697	CDD:222983	217/531 (41%)
		BACK	283..382	CDD:285009	40/98 (41%)
		Kelch	430..475	CDD:128874	18/45 (40%)
		Kelch_1	464..509	CDD:279660	17/44 (39%)
		KELCH repeat	465..508	CDD:276965	17/42 (40%)
		KELCH repeat	512..556	CDD:276965	19/43 (44%)
		Kelch	525..569	CDD:128874	20/43 (47%)
		KELCH repeat	559..602	CDD:276965	17/42 (40%)
		Kelch	570..616	CDD:128874	19/45 (42%)
		Kelch_1	605..656	CDD:279660	22/50 (44%)
		KELCH repeat	606..657	CDD:276965	21/50 (42%)
		KELCH repeat	659..698	CDD:276965	18/38 (47%)
		Kelch	670..714	CDD:128874	20/45 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820