DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Kbtbd3

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001101591.1	Gene:	Kbtbd3 / 315394	RGDID:	1310895	Length:	607	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	146/578 - (25%)
Similarity:	239/578 - (41%)	Gaps:	78/578 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSAL 92
            :.:..|......|..:.::::....||.||||...:|.|||..||.|.....:|:  :.:...|:
  Rat    37 VLQSFREQNVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTI--TNLSSKAV 99

  Fly    93 ESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQ 157
            ::.::|.|:|:.||.:.||:.....:||||:|.:..||:.|||......|.|.:.:.:||....|
  Rat   100 KAFLDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLSDSYGSAQ 164

  Fly   158 LIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSEL 222
            |......::..:|..:.:|.:||.::...|.:.:..|||||..||::.:|.:.|:||..:.|.:.
  Rat   165 LFSHTLYFVQHHFHLLFKSRDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTWIKYNVESRQKH 229

  Fly   223 FPQVLAAVRLPLLSPQFLADRVAREELIRSSHQC-RDLLDEAKDFHLMPERRGLLQSFRTRQRSG 286
            .|.::|.|||..||...|.|.:..||.:..|..| ..::|..|               |.:..||
  Rat   230 LPHLIAKVRLHQLSEASLQDCLLNEEYLLKSTNCFETIVDAIK---------------RVQGSSG 279

  Fly   287 EF------FTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMM-RSRVGVAVLNGKLYAF 344
            .|      .|.:...:......||:..|. .|:..|..||:..|..:: .....::....|::..
  Rat   280 LFPDARPSTTEKYIFIHKTEENGENQYTF-CYNIKTDSWKILSQSHLIDLPGSSLSSYGEKIFLT 343

  Fly   345 GGFNG----TERLSTVEVYD----------PRKNKWSQGCAMLCKRSA-VGVAALDDCIYVCG-- 392
            ||..|    ..||...|.|.          |.||::.....|...|:. ..|.||:....:.|
  Rat   344 GGCKGKCCRKVRLHIAESYHDATDQTWCYCPIKNEFFFVSTMKTPRTMHTSVTALNRLFVIGGKT 408

  Fly   393 -GYDGVTSLNTVEVYYPKSNTWKTVAQMMK---YRSAGGVTQLNGYVYALGGHDGLSIFDSVE-- 451
             |...:.||..||.|.|.|..|.:|:.:.:   |..|.....:   :|.||..  :.|.|:..
  Rat   409 RGSQDIKSLLDVESYDPLSKEWTSVSPLPRGIYYPEASACQNV---IYVLGSE--VEIADAFNPS 468

  Fly   452 -----RYDQAEDVWVKMSPMLNRRCRLGVATL------NGKIYVCGGYCGNSFLRSVECYD--PQ 503
                 :|:...|.|   |.::....:...|||      |..:|:|.       |.:.:.|.  |.
  Rat   469 LDCFFKYNATTDQW---SELVAEFGQFFHATLIKAVPVNCTLYICD-------LSTYKVYSFCPD 523

  Fly   504 TDTWKLVTPMNCKRSRVALAANMGKLWAIGG-YDGESNLSTVEVYDPETDKWTFMPPM 560
            |..||......|............|::.:|| |..:.....|:||.....:|..:.||
  Rat   524 TCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSSRSEWEEVSPM 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	32/105 (30%)
		PHA03098	36..510	CDD:222983	134/517 (26%)
		BACK	143..245	CDD:285009	31/101 (31%)
		Kelch	292..339	CDD:128874	8/47 (17%)
		KELCH repeat	329..372	CDD:276965	11/56 (20%)
		Kelch	340..386	CDD:128874	16/60 (27%)
		KELCH repeat	376..417	CDD:276965	14/44 (32%)
		Kelch	387..433	CDD:128874	13/51 (25%)
		KELCH repeat	423..466	CDD:276965	10/49 (20%)
		Kelch	435..480	CDD:128874	12/57 (21%)
		Kelch_1	469..514	CDD:279660	12/52 (23%)
		KELCH repeat	470..514	CDD:276965	12/51 (24%)
		Kelch_1	517..560	CDD:279660	8/43 (19%)
		KELCH repeat	517..560	CDD:276965	8/43 (19%)
Kbtbd3	NP_001101591.1	BTB_POZ_KBTBD3_BKLHD3	24..153	CDD:349580	36/117 (31%)
		PHA03098	38..595	CDD:222983	146/577 (25%)
		KELCH repeat	330..385	CDD:276965	11/54 (20%)
		KELCH repeat	389..437	CDD:276965	15/47 (32%)
		KELCH repeat	440..485	CDD:276965	11/52 (21%)
		KELCH repeat	537..582	CDD:276965	10/45 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900