Protein Alignment KLHL18 and Klhl15

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001101491.1
• Gene: Klhl15 / 314111
• RGDID: 1563101
• Length: 604
• Species: Rattus norvegicus
• Alignment Length: 589
• Identity: 156/589 - (26%)
• Similarity: 259/589 - (43%)
• Gaps: 83/589 - (14%)

  Fly    18 HDKLFGESF-PLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEIT 81
            ||......| .|::|    |.|.||||.:||..|.||:.:||....||..|||.:|.|....:|.
  Rat    13 HDTSVSAGFRALYEE----GLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIH 73

  Fly    82 MKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGI 146
            :|  .:..:....::.::|.|.:.:....|..::..|.::||..|...|.|||:::....|...|
  Rat    74 LK--GLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEI 136

  Fly   147 RTFADSM-----ICRQLIDAADKYIDQNFAKVSQSEEFLA-LDCEQLLELMRRDELNVRTEEVIF 205
            ....|..     ..|:.:||   ::..||..:....:||: |..|:|:..:..|.|:...|..::
  Rat   137 MRLLDDFGVNIEGVREKLDA---FLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELY 198

  Fly   206 EACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMP 270
            ||...|::: :.:|......::..:|..|::|..:.::|...|..|.|.|.|..:|:|.::....
  Rat   199 EAVQSWLRH-DRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNV 262

  Fly   271 ERRGLLQSFRTRQRSGE----FFTGQIYAVGGLASTGESVSTVEIYDPLTKK----WKM-GEQMS 326
            .::.||....:|.||.:    .|.|.|         |.|:...:|.  |.||    |:: |.|:.
  Rat   263 HQQPLLDMKSSRIRSAKPQTTVFRGMI---------GHSMVNSKIL--LLKKPRVWWELEGPQVP 316

  Fly   327 MMRSRVGVAVLNGKLYAFGG--------FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAA 383
            :...  .:|::|..::..||        |:.:   |.|..||||:|.|.:...|...||...|..
  Rat   317 LRPD--CLAIVNNFVFLLGGEELGPDGEFHAS---SKVFRYDPRQNSWLRMADMSVPRSEFAVGV 376

  Fly   384 LDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTV--AQMMKYRSAGGVTQLNGYVYALGGHDGLS- 445
            :...||...|.....:..:.|.|...::.|:.|  ..:.||...|  |.||..::..||....|
  Rat   377 IGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEG--TVLNNKLFITGGITSSST 439

  Fly   446 -----IFD-----SVERYDQAEDV----WVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLR- 495
                 :||     ::|:..:...|    |...|.|...||...:.:.|||:||.||.|  ..||
  Rat   440 SKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVC--VILRA 502

  Fly   496 --------SVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGG--YDGESNLSTVEVYDPE 550
                    |.|.|:|.||.|.::..|...||...:.....::..:||  |:|..: .::..:||:
  Rat   503 SFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYS-DSILTFDPD 566

  Fly   551 TDKW 554
            .:||
  Rat   567 ENKW 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	36/117 (31%)
		PHA03098	36..510	CDD:222983	140/522 (27%)
		KELCH repeat	329..372	CDD:276965	13/50 (26%)
		KELCH repeat	376..417	CDD:276965	10/42 (24%)
		KELCH repeat	423..466	CDD:276965	13/57 (23%)
		KELCH repeat	470..514	CDD:276965	19/52 (37%)
		Kelch_1	517..560	CDD:396078	10/40 (25%)
		KELCH repeat	517..560	CDD:276965	10/40 (25%)
Klhl15	NP_001101491.1	BTB_POZ_KLHL15	1..137	CDD:349553	39/129 (30%)
		PHA03098	33..576	CDD:222983	148/565 (26%)
		BACK_KLHL15	128..235	CDD:350529	23/110 (21%)
		KELCH repeat	321..365	CDD:276965	13/46 (28%)
		Kelch 1	328..379		15/53 (28%)
		KELCH repeat	369..412	CDD:276965	10/42 (24%)
		Kelch 2	381..426		12/46 (26%)
		KELCH repeat	417..474	CDD:276965	14/58 (24%)
		Kelch 3	428..473		8/44 (18%)
		KELCH repeat	478..529	CDD:276965	19/52 (37%)
		Kelch 4	489..542		18/54 (33%)
		KELCH repeat	532..572	CDD:276965	10/40 (25%)
		Kelch 5	544..590		8/28 (29%)