Protein Alignment KLHL18 and Klhl13

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001388060.1
• Gene: Klhl13 / 313445
• RGDID: 1559646
• Length: 660
• Species: Rattus norvegicus
• Alignment Length: 572
• Identity: 175/572 - (30%)
• Similarity: 289/572 - (50%)
• Gaps: 43/572 - (7%)

  Fly    29 FKEIRRMGKLCDVTLKV--EDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSA 91
            |.::|..|.||||||..  .|..:..|||::|:...||.||||..|.|..:  :.:|...:....
  Rat    87 FDQLRLDGLLCDVTLMPGDTDDAYPVHRVMMASASDYFKAMFTGGMKEQEL--MCIKLHGVSRVG 149

  Fly    92 LESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICR 156
            |..:|:::|:.::.::...:|:.:..|||||:..|.|.|..||||.....|.:.:...|::....
  Rat   150 LRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYHLT 214

  Fly   157 QLIDAADKYID----QNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAED 217
            ::    |||::    :|||.:..:.|||.|..|:|..::..:.|...||..:|:|..:|:: .|:
  Rat   215 EV----DKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELELFKATCRWLR-LEE 274

  Fly   218 KRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTR 282
            .|.::..:::..:|.||::||.|.:.|...:.:|:.:.|.:||.||.::.:||..:.::||.||.
  Rat   275 PRMDVAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPFMQPVMQSDRTA 339

  Fly   283 QRSGEFFTGQIYAVGGLASTGESVS-TVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGG 346
            .||.   |..:..:||:......|| .:.:||..|.:||....|...|.:.|:||:...||..||
  Rat   340 IRSD---TTHLVTLGGVLRQQLVVSKELRMYDEKTHEWKSLAPMDAPRYQHGIAVIGNFLYVVGG 401

  Fly   347 -----FNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVY 406
                 ..|...:.||..:|||.|||.|..::..||:...::||...:|..||.:....|.|||.|
  Rat   402 QSNYDTKGKTAVDTVFRFDPRYNKWIQVASLNEKRTFFHLSALKGFLYAVGGRNAAGELPTVECY 466

  Fly   407 YPKSNTWKTVAQMMK--YRSAGGVTQLNGYVYALGG--HDGLSIFDSVERYDQAEDVWVKMSPML 467
            .|::|.|..||:|.:  |..||  |...|.:|..||  ||  :....:..:|...|.|::.:||.
  Rat   467 NPRTNEWTYVAKMNEPHYGHAG--TVYGGVMYISGGITHD--TFQKELMCFDPDTDKWIQKAPMT 527

  Fly   468 NRRCRLGVATLNGKIYVCGGYCGNSF--------LRSVECYDPQTDTWKLVTPMNCKRSRVALAA 524
            ..|....:.|:..::||.|   ||.|        :.|.|.|.|..|.|..:..|...:|.|.:|.
  Rat   528 TVRGLHCMCTVGDRLYVIG---GNHFRGTSDYDDVLSCEYYSPILDQWTPIASMLRGQSDVGVAV 589

  Fly   525 NMGKLWAIGGYDGESN--LSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            ...|::.:|||...:.  :..|:.||||.::|..:..:....||:.|..:.:
  Rat   590 FENKIYVVGGYSWNNRCMVEIVQKYDPEKNEWHKVFDLPESLGGIRACTLTV 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	38/109 (35%)
		PHA03098	36..510	CDD:222983	156/497 (31%)
		KELCH repeat	329..372	CDD:276965	18/47 (38%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		KELCH repeat	423..466	CDD:276965	12/44 (27%)
		KELCH repeat	470..514	CDD:276965	14/51 (27%)
		Kelch_1	517..560	CDD:396078	13/44 (30%)
		KELCH repeat	517..560	CDD:276965	13/44 (30%)
Klhl13	NP_001388060.1	BTB_POZ_KLHL9_13	74..201	CDD:349548	39/115 (34%)
		PHA03098	97..640	CDD:222983	171/559 (31%)
		KELCH repeat	384..432	CDD:276965	18/47 (38%)
		KELCH repeat	436..480	CDD:276965	16/43 (37%)
		KELCH repeat	483..528	CDD:276965	15/48 (31%)
		KELCH repeat	530..579	CDD:276965	14/51 (27%)
		KELCH repeat	582..629	CDD:276965	13/46 (28%)