Protein Alignment KLHL18 and Klhl5

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001040558.1
• Gene: Klhl5 / 305351
• RGDID: 1309661
• Length: 708
• Species: Rattus norvegicus
• Alignment Length: 572
• Identity: 230/572 - (40%)
• Similarity: 342/572 - (59%)
• Gaps: 18/572 - (3%)

  Fly    11 DQYF-VYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAE 74
            |::| ...|.:   ::|...:...|..:||||.|...|:...|||:||::...||.|||||::.|
  Rat   147 DEFFQALNHAE---QTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVRE 208

  Fly    75 SRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFH 139
            :|.:||.|:  .:||::|.|||.|.|:|::.:..:|::.|:..|..||||.|.:||..||:.:.|
  Rat   209 ARQEEIKME--GVEPNSLWSLIQYAYTGRLELKEENIECLLSTACLLQLSQVVEACCKFLMKQLH 271

  Fly   140 PHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVI 204
            |.|.||||:|||:..|..|...|..|..::|.:|.:::||:.|...::.:|:..|::|:..||.|
  Rat   272 PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETI 336

  Fly   205 FEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLM 269
            ..|.:.||::..::|.:...::||.:|||||:|||||| :....|.|...:|:.|:.||..:||:
  Rat   337 LNALLTWVRHDLEQRQKDLSKLLAYIRLPLLAPQFLAD-MENNALFRDDIECQKLIMEAMKYHLL 400

  Fly   270 PERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGV 334
            ||||.:|||.||:.|...  .|.::||||:.|| :..:::|.||..|..|.....|:..|.:.||
  Rat   401 PERRPMLQSPRTKPRKST--VGTLFAVGGMDST-KGATSIEKYDLRTNMWTPVANMNGRRLQFGV 462

  Fly   335 AVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS 399
            |||:.|||..||.:|.:.|:|||.|:|:...||....|...|..:|||.|:..:|..||:||.:.
  Rat   463 AVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY 527

  Fly   400 LNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMS 464
            |||||.:.|::..|..||.|...||..||..|:|.:||:||.||.|...|||.:|...:.|...:
  Rat   528 LNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCA 592

  Fly   465 PMLNRRCRLGVATLNGKIYVCGGY-CGNSFLRS-----VECYDPQTDTWKLVTPMNCKRSRVALA 523
            .|..||..:||.|.||.:|..||: ...|.|.|     ||.|||:||.|..|..|:..|..|.:.
  Rat   593 QMSKRRGGVGVTTWNGLLYAIGGHDAPTSNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC 657

  Fly   524 ANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRIE 575
            ....||:|:|||||::.|:.||.|||:|::||.:.|:|.  |..||.|:.::
  Rat   658 LLGDKLYAVGGYDGQTYLNIVEAYDPQTNEWTQVAPLCL--GRAGACVVTVK 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	46/116 (40%)
		PHA03098	36..510	CDD:222983	198/479 (41%)
		KELCH repeat	329..372	CDD:276965	20/42 (48%)
		KELCH repeat	376..417	CDD:276965	17/40 (43%)
		KELCH repeat	423..466	CDD:276965	18/42 (43%)
		KELCH repeat	470..514	CDD:276965	21/49 (43%)
		Kelch_1	517..560	CDD:396078	19/42 (45%)
		KELCH repeat	517..560	CDD:276965	19/42 (45%)
Klhl5	NP_001040558.1	PHA03098	173..695	CDD:222983	219/527 (42%)
		KELCH repeat	457..500	CDD:276965	20/42 (48%)
		KELCH repeat	504..548	CDD:276965	19/43 (44%)
		KELCH repeat	551..594	CDD:276965	18/42 (43%)
		KELCH repeat	598..648	CDD:276965	21/49 (43%)
		KELCH repeat	651..694	CDD:276965	19/42 (45%)