Protein Alignment KLHL18 and Klhl22

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_006248761.1
• Gene: Klhl22 / 303792
• RGDID: 1306288
• Length: 720
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 155/565 - (27%)
• Similarity: 257/565 - (45%)
• Gaps: 36/565 - (6%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|..|.|.||.|.||.:...|||::|||:..||..||...:.|...:|:.:  ..:..:|:..::
  Rat   129 LRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLI--HGVSYNAMCQIL 191

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            :::|:.::.:...|||..:|.|..||:..:...|..||:|.....|:|.:...|:.....:|...
  Rat   192 HFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLNRLTQQ 256

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELF--- 223
            .|.||.:||...|:::::..|..|::..|:..:.|.|..|..::|..:.:....|..:::..
  Rat   257 LDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSMEQVQADQISLH 321

  Fly   224 --PQVLAAVRLPLLSP---QFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQ 283
              |::|..||.||:..   |.|.|::....|       ||.:..|..:|.....:..||...|..
  Rat   322 EPPKLLETVRFPLMEAEVLQRLHDKLGPSPL-------RDTVASALMYHRNESLQPSLQGPHTEL 379

  Fly   284 RSGEFFTGQIYAVGGLASTGESV--STVEIYDPLTKKWK-MGEQMSMMRSRVGVAVLNGKLYAFG 345
            || :|..  :...||:.||..::  ...:..:||..:|| ....::...|..|:||||..:|..|
  Rat   380 RS-DFQC--VVGFGGIHSTPSTILSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIG 441

  Fly   346 GFN---GTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYY 407
            |.|   |....|....||||.|:|.|..::..:.:.:.|..:...||...|.|...:|:.||.|.
  Rat   442 GDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLCVCVVGKYIYAVAGRDYHNNLSAVERYD 506

  Fly   408 PKSNTWKTVAQMMK--YRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRR 470
            |.:|:|:.||.:.|  |..||  |.|.|.:|...|..|.........||...:.|..::....||
  Rat   507 PATNSWEYVAPLKKEVYAHAG--TTLQGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRR 569

  Fly   471 CRLGVATLNGKIYVCGGYCGNSFLR----SVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWA 531
            ...|:|.|..|::|.||...::..|    .|.||...:..|..|.|:........:|....:::.
  Rat   570 AWHGMAALLDKLFVIGGSNNDAGYRRDVHQVACYSCTSRQWSSVCPLPAGHGEPGIAVLDNRIYV 634

  Fly   532 IGG--YDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            :||  ::..|....|.:||.|.|.|...|.:.....|:.|.|:.:
  Rat   635 LGGRSHNRGSRTGYVHIYDMEKDCWEEGPQLNNSISGLAACVLTL 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	32/104 (31%)
		PHA03098	36..510	CDD:222983	138/493 (28%)
		KELCH repeat	329..372	CDD:276965	19/45 (42%)
		KELCH repeat	376..417	CDD:276965	12/40 (30%)
		KELCH repeat	423..466	CDD:276965	11/42 (26%)
		KELCH repeat	470..514	CDD:276965	15/47 (32%)
		Kelch_1	517..560	CDD:396078	11/44 (25%)
		KELCH repeat	517..560	CDD:276965	11/44 (25%)
Klhl22	XP_006248761.1	BTB_POZ_KLHL22	113..237	CDD:349560	33/109 (30%)
		PHA03098	138..678	CDD:222983	151/553 (27%)
		BACK_KLHL22	233..336	CDD:350536	24/102 (24%)
		KELCH repeat	380..421	CDD:276965	11/43 (26%)
		KELCH repeat	426..471	CDD:276965	19/44 (43%)
		KELCH repeat	475..519	CDD:276965	14/43 (33%)
		KELCH repeat	522..567	CDD:276965	12/46 (26%)
		KELCH repeat	569..617	CDD:276965	15/47 (32%)
		KELCH repeat	620..666	CDD:276965	11/45 (24%)