Protein Alignment KLHL18 and Klhl10

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001001510.1
• Gene: Klhl10 / 303533
• RGDID: 1303290
• Length: 608
• Species: Rattus norvegicus
• Alignment Length: 549
• Identity: 171/549 - (31%)
• Similarity: 266/549 - (48%)
• Gaps: 28/549 - (5%)

  Fly    20 KLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTN--NMAESRIKEITM 82
            |:...:..:|.|:|..||||||.:||....|:||:.:|.:...||.|:||:  |..|.::..|
  Rat    20 KMSAMTCEIFNELRLEGKLCDVVIKVNGFEFNAHKNILCSCSSYFRALFTSGWNNTEKKVYNI-- 82

  Fly    83 KESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIR 147
              ..|.|..::.:|.|.|:..|.|...||:.|:..|....:..:...|..||.|.....|.:||.
  Rat    83 --PGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGIC 145

  Fly   148 TFADSMICRQLIDAADKYIDQNFAK-VSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKW 211
            .|.|...|.:|...|..:|..||.: |..|.|||.|...:|.:::.:|||||:.|:.:|||.:||
  Rat   146 KFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKW 210

  Fly   212 VKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLL 276
            :.:....|.:....:|..|||.|:..::..:.|...:.::.|.:|:.::..|..         .:
  Rat   211 ISHDPQNRKQHISVLLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK---------AM 266

  Fly   277 QSFRTRQRSGEFFTGQ----------IYAVGGLASTGESVSTVEIYDPLTKKW-KMGEQMSMMRS 330
            ........|...||..          ::|:||. |.|...:.:|.||....:| .:..:....|:
  Rat   267 YDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGW-SGGSPTNAIEAYDARADRWVNVTCEEESPRA 330

  Fly   331 RVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYD 395
            ..|.|.|.|.:|..|||:..:..::|:.:||.|..|.|...|..:|..|.|..|.:.||..||:|
  Rat   331 YHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLSNFIYAMGGFD 395

  Fly   396 GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVW 460
            |...|||.|.|.|::|.|..:|.|.:.||....|.|.|.||..||.:|.....:.|.|:...:.|
  Rat   396 GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQW 460

  Fly   461 VKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAAN 525
            ..::||.:||..:||......:|..||:.|.:.|||.|.|.|..:||:.:..|...||...:...
  Rat   461 TVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVV 525

  Fly   526 MGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            ...|:.:||::|.:....||.||.:||:|
  Rat   526 DDLLFVVGGFNGFTTTFNVECYDEKTDEW 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	38/118 (32%)
		PHA03098	36..510	CDD:222983	153/487 (31%)
		KELCH repeat	329..372	CDD:276965	15/42 (36%)
		KELCH repeat	376..417	CDD:276965	18/40 (45%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		KELCH repeat	470..514	CDD:276965	15/43 (35%)
		Kelch_1	517..560	CDD:396078	13/38 (34%)
		KELCH repeat	517..560	CDD:276965	13/38 (34%)
Klhl10	NP_001001510.1	PHA03098	36..572	CDD:222983	167/533 (31%)
		Kelch 1	292..339		13/47 (28%)
		KELCH repeat	329..372	CDD:276965	15/42 (36%)
		Kelch 2	340..386		15/45 (33%)
		KELCH repeat	376..420	CDD:276965	19/43 (44%)
		Kelch 3	388..433		20/44 (45%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		Kelch 4	434..480		14/45 (31%)
		KELCH repeat	470..513	CDD:276965	15/42 (36%)
		Kelch 5	481..527		15/45 (33%)
		KELCH repeat	517..560	CDD:276965	13/38 (34%)
		Kelch 6	529..574		11/26 (42%)