Protein Alignment KLHL18 and Klhl28

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001100205.1
• Gene: Klhl28 / 299103
• RGDID: 1311326
• Length: 571
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 203/532 - (38%)
• Similarity: 293/532 - (55%)
• Gaps: 15/532 - (2%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:..:|||:.|:|.|....||:||||:..|||.||||.|::|....|:..:  .|:.:||::::
  Rat    28 LRQHHELCDIILRVGDVKIHAHKVVLASISPYFKAMFTGNLSEKENSEVEFQ--CIDEAALQAIV 90

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            .|.|:|.|.|....|::|:..|:.||:..|...|.:||.|:..|.|.:||..||::..|..|..|
  Rat    91 EYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCTFLESQLDPGNCIGISRFAETYGCHDLYLA 155

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            |.|:|.|||..|.|:|||..|....|.|::..|.|||.|||.:|.|...|:||...:|.:...|:
  Rat   156 ATKFICQNFESVCQTEEFFELTHGDLDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQL 220

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQS-FRTRQRSGEFFT 290
            |.:|||||||.:||........|||....|:.||:||..:|.|||.|...|: ..||.|..   .
  Rat   221 LNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCA---P 282

  Fly   291 GQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTER--- 352
            ..:.||||.:.....:.:||:|.|....|.....:::.|...|:.||:.|:|..||...:.|
  Rat   283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIETSVRPGV 347

  Fly   353 -----LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNT 412
                 .::||.::|..|.|:....|...||.:||..|...:|..|||||.:.|.:||.|.||...
  Rat   348 TVRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGEVYALGGYDGQSYLQSVEKYIPKIRQ 412

  Fly   413 WKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVAT 477
            |:.||.|...||......|:|.:||:||: |.:..:||||||.::|.|..::.|.::|...||..
  Rat   413 WQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWETVASMADKRIHFGVGV 476

  Fly   478 LNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLS 542
            :.|.|:|.||:.|.|.|.|:|.|||..:.|.:..||...|:.|..|.....|:.:||:.|.|.|:
  Rat   477 MLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLN 541

  Fly   543 TVEVYDPETDKW 554
            ||:.|||.:|.|
  Rat   542 TVQKYDPISDTW 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	40/104 (38%)
		PHA03098	36..510	CDD:222983	184/482 (38%)
		KELCH repeat	329..372	CDD:276965	14/50 (28%)
		KELCH repeat	376..417	CDD:276965	18/40 (45%)
		KELCH repeat	423..466	CDD:276965	17/42 (40%)
		KELCH repeat	470..514	CDD:276965	18/43 (42%)
		Kelch_1	517..560	CDD:396078	16/38 (42%)
		KELCH repeat	517..560	CDD:276965	16/38 (42%)
Klhl28	NP_001100205.1	PHA03098	35..553	CDD:222983	200/523 (38%)
		KELCH repeat	321..372	CDD:276965	14/50 (28%)
		KELCH repeat	376..419	CDD:276965	20/42 (48%)
		KELCH repeat	423..465	CDD:276965	17/42 (40%)
		KELCH repeat	469..513	CDD:276965	18/43 (42%)
		KELCH repeat	516..559	CDD:276965	16/38 (42%)