DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and Klhl2

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_001406494.1 Gene:Klhl2 / 290692 RGDID:1306388 Length:593 Species:Rattus norvegicus


Alignment Length:556 Identity:233/556 - (41%)
Similarity:335/556 - (60%) Gaps:10/556 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 ESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE 88
            ::|.:..|:|....|||||:..||....||||||||..|||:||||..|:|||.|.:.:||  ::
  Rat    41 KAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE--VD 103

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            ...|..||:|||:.::::..:|||.|:..|..|||.:|:..|..||.|:.||.|.||||.|||..
  Rat   104 GWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMH 168

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDK 218
            .|..|::.|:.|.:|:||.|..|||||.|..||:..|:..|:|.:.:||.:|||.:.||.:.:|.
  Rat   169 ACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV 233

  Fly   219 RSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMP-ERRGLLQSFRTR 282
            |.|...:::..||||||..::|..||..|.|:::|..|:|.|.||..:||:| |:|.|::|.|||
  Rat   234 RQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTR 298

  Fly   283 QRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGF 347
            .|:.......:..|||.|.  :::.:||.||...::|....::...|.|.|:..:.|.::|.|||
  Rat   299 LRTPMNLPKLMVVVGGQAP--KAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF 361

  Fly   348 NGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNT 412
            ||:.|:.||:.|||.|::|:....|..:||.:|.|.|:..:|..||:||.|.|::||.|..|||.
  Rat   362 NGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNE 426

  Fly   413 WKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLS--IFDSVERYDQAEDVWVKMSPMLNRRCRLGV 475
            |..||.|...||:.||..:.|.:||:||:||.|  ...:||.|:...:.|..::.|..||...||
  Rat   427 WFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGV 491

  Fly   476 ATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMN-CKRSRVALAANMGKLWAIGGYDGES 539
            ..||..:|..||:.|....:|||.|||.|:.|:.|..|| |:|:....|.| |.|:.:||.||..
  Rat   492 GVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVN-GLLYVVGGDDGSC 555

  Fly   540 NLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRIE 575
            ||::||.|:|.|||||.: ..|..:|...|||..|:
  Rat   556 NLASVEYYNPTTDKWTVV-SSCMSTGRSYAGVTVID 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 50/112 (45%)
PHA03098 36..510 CDD:222983 200/476 (42%)
KELCH repeat 329..372 CDD:276965 18/42 (43%)
KELCH repeat 376..417 CDD:276965 19/40 (48%)
KELCH repeat 423..466 CDD:276965 16/44 (36%)
KELCH repeat 470..514 CDD:276965 18/43 (42%)
Kelch_1 517..560 CDD:396078 20/42 (48%)
KELCH repeat 517..560 CDD:276965 20/42 (48%)
Klhl2NP_001406494.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29
BTB_POZ_KLHL2_Mayven 35..155 CDD:349647 51/115 (44%)
PHA03098 56..573 CDD:222983 223/521 (43%)
BACK_KLHL2_Mayven 153..282 CDD:350587 56/128 (44%)
Kelch 1 308..353 12/46 (26%)
KELCH repeat 343..386 CDD:276965 18/42 (43%)
Kelch 2 354..400 20/45 (44%)
KELCH repeat 390..434 CDD:276965 21/43 (49%)
Kelch 3 402..447 21/44 (48%)
Kelch 4 449..496 17/46 (37%)
KELCH repeat 486..530 CDD:276965 18/43 (42%)
Kelch 5 497..543 19/46 (41%)
KELCH repeat 533..579 CDD:276965 21/47 (45%)
Kelch 6 545..591 22/47 (47%)
Blue background indicates that the domain is not in the aligned region.

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