DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Klhl1

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001381602.1	Gene:	Klhl1 / 290426	RGDID:	1307452	Length:	750	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	230/578 - (39%)
Similarity:	339/578 - (58%)	Gaps:	19/578 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFT 69
            |:|..|:.|....|.:   :||...:...:..:||||.|.|.::...|||:||::...||.||||
  Rat   183 DSSSSEEFYQAVHHAE---QSFRKMENYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFT 244

  Fly    70 NNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFL 134
            :::.|::.:||.|:  .|:|:||..|:.:.|:|.:.:....::||:..|..|||..|.:.|..||
  Rat   245 SDVCEAKQEEIKME--GIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFL 307

  Fly   135 ISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVR 199
            :...||.|.||||.|||:..|.:|:..|..|..:|..:|.:::|||.|..|:|.:|:..|::||.
  Rat   308 MKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVP 372

  Fly   200 TEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAK 264
            .||.||.|.|.||||...:|......:||.:|||||.||.||| :....|.::..:|:.|:.||.
  Rat   373 DEETIFHALMMWVKYDMQRRCGDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAM 436

  Fly   265 DFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMR 329
            .:||:||||.|:||.||:.|...  .|.:|||||: ...:..:|:|.||..|..|.....|:..|
  Rat   437 KYHLLPERRTLMQSPRTKPRKST--VGTLYAVGGM-DNNKGATTIEKYDLRTNLWIQAGMMNGRR 498

  Fly   330 SRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGY 394
            .:.||||::.||:..||.:|.:.|:|||.|:|:...|:....|...|..:||..|:..||..||:
  Rat   499 LQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGH 563

  Fly   395 DGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDV 459
            ||.:.|||||.:.|:|..|..||.|...||..||..|||.:|::||.||.|...|:|.||...:.
  Rat   564 DGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNK 628

  Fly   460 WVKMSPMLNRRCRLGVATLNGKIYVCGG-------YCGNSFLRSVECYDPQTDTWKLVTPMNCKR 517
            |...:||..||..:||||.:|.:|..||       :| :..|..||.|||:||||.:|.|::..|
  Rat   629 WSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHC-SRLLDYVERYDPKTDTWTMVAPLSMPR 692

  Fly   518 SRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRIE 575
            ..|.:.....:|:|:|||||::.|:|:|.|||:|::||.|..:  :.|..||.|:.|:
  Rat   693 DAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASL--NIGRAGACVVVIK 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	37/105 (35%)
		PHA03098	36..510	CDD:222983	197/480 (41%)
		BACK	143..245	CDD:285009	46/101 (46%)
		Kelch	292..339	CDD:128874	17/46 (37%)
		KELCH repeat	329..372	CDD:276965	17/42 (40%)
		Kelch	340..386	CDD:128874	17/45 (38%)
		KELCH repeat	376..417	CDD:276965	18/40 (45%)
		Kelch	387..433	CDD:128874	22/45 (49%)
		KELCH repeat	423..466	CDD:276965	18/42 (43%)
		Kelch	435..480	CDD:128874	19/44 (43%)
		Kelch_1	469..514	CDD:279660	23/51 (45%)
		KELCH repeat	470..514	CDD:276965	22/50 (44%)
		Kelch_1	517..560	CDD:279660	19/42 (45%)
		KELCH repeat	517..560	CDD:276965	19/42 (45%)
Klhl1	NP_001381602.1	PHA03098	208..730	CDD:222983	215/528 (41%)
		KELCH repeat	498..541	CDD:276965	17/42 (40%)
		KELCH repeat	545..589	CDD:276965	20/43 (47%)
		KELCH repeat	592..635	CDD:276965	18/42 (43%)
		KELCH repeat	639..689	CDD:276965	22/50 (44%)
		KELCH repeat	692..736	CDD:276965	19/45 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920