DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Klhl8

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001099465.1	Gene:	Klhl8 / 289457	RGDID:	1304685	Length:	621	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	212/575 - (36%)
Similarity:	324/575 - (56%)	Gaps:	29/575 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DQYFVYK--------HDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAM 67
            |..|:::        |..|.|     |.|   .|:||||||||..:..|.|::.||..||||.||
  Rat    40 DDSFIFEANEAWKDFHGSLLG-----FYE---NGELCDVTLKVGSKLISCHKLALACVIPYFRAM 96

  Fly    68 FTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACAS 132
            |.:.|:|::...|.:::  .:..|:|.|:.:|||.::.:...|||.|:..|..||:..|..||..
  Rat    97 FLSEMSEAKQALIEIRD--FDGDAVEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCE 159

  Fly   133 FLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELN 197
            ::...|||.|.|.:|.||:|.....|:|.||:|..::|.:|.:.|:|:::..:.|.:|:...:||
  Rat   160 YMKLHFHPSNCLAVRAFAESHNRTDLMDMADQYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLN 224

  Fly   198 VRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDE 262
            :.:|:.::.|.:||:........:...:.||.||||||...||...||:|::::.:.:|||||||
  Rat   225 IDSEKQVYSAAIKWLLANPQHHPKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDE 289

  Fly   263 AKDFHL------MPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKM 321
            |:::||      :|:   ...|.||..|  :...|.::.|||...:|:...::|.|...|..|..
  Rat   290 ARNYHLHLSSKPVPD---FEYSVRTTPR--KHTAGVLFCVGGRGGSGDPFRSIECYSINTNSWFF 349

  Fly   322 GEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDD 386
            |.:|:..|..|||..:.||:||.||.:|.|.|.::|::||..|||....:|..||..:.:|:|..
  Rat   350 GPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMVKASMNTKRRGIALASLGG 414

  Fly   387 CIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVE 451
            .||..||.|..|..:.||.|..:|:.|.|||.|...|...|...|..:|||:||:||::...|||
  Rat   415 PIYAIGGLDDNTCFSDVERYDIESDQWSTVAPMNTPRGGVGSVALINHVYAVGGNDGVASLSSVE 479

  Fly   452 RYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCK 516
            ||....|.||::..|..||...||:.|:|.:||.||:..||.|.|||.|||:::.|..|..:...
  Rat   480 RYHPHLDKWVEVKEMGQRRAGNGVSELHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTP 544

  Fly   517 RSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGV 571
            |..|.:|..|||::|:||::|.:.|:|||.:||..:||..:.|:.....|.|..|
  Rat   545 RGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNKWELVGPVSHCRAGAGVAV 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	41/105 (39%)
		PHA03098	36..510	CDD:222983	182/479 (38%)
		BACK	143..245	CDD:285009	32/101 (32%)
		Kelch	292..339	CDD:128874	14/46 (30%)
		KELCH repeat	329..372	CDD:276965	19/42 (45%)
		Kelch	340..386	CDD:128874	19/45 (42%)
		KELCH repeat	376..417	CDD:276965	15/40 (38%)
		Kelch	387..433	CDD:128874	18/45 (40%)
		KELCH repeat	423..466	CDD:276965	18/42 (43%)
		Kelch	435..480	CDD:128874	21/44 (48%)
		Kelch_1	469..514	CDD:279660	21/44 (48%)
		KELCH repeat	470..514	CDD:276965	20/43 (47%)
		Kelch_1	517..560	CDD:279660	18/42 (43%)
		KELCH repeat	517..560	CDD:276965	18/42 (43%)
Klhl8	NP_001099465.1	BTB	58..162	CDD:279045	43/113 (38%)
		PHA03098	61..536	CDD:222983	183/484 (38%)
		BACK	170..272	CDD:285009	32/101 (32%)
		Kelch	320..367	CDD:128874	14/46 (30%)
		KELCH repeat	357..400	CDD:276965	19/42 (45%)
		Kelch	368..414	CDD:128874	19/45 (42%)
		KELCH repeat	404..448	CDD:276965	17/43 (40%)
		Kelch	416..459	CDD:128874	17/42 (40%)
		KELCH repeat	451..496	CDD:276965	19/44 (43%)
		Kelch	462..508	CDD:128874	21/45 (47%)
		KELCH repeat	498..543	CDD:276965	20/44 (45%)
		Kelch	509..555	CDD:128874	18/45 (40%)
		KELCH repeat	545..587	CDD:276965	18/41 (44%)
		Kelch	556..601	CDD:128874	17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820