DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Ivns1abp

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_006250050.1	Gene:	Ivns1abp / 289089	RGDID:	1306290	Length:	642	Species:	Rattus norvegicus

Alignment Length:	639	Identity:	174/639 - (27%)
Similarity:	297/639 - (46%)	Gaps:	98/639 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMA 73
            :.:.|.:::.:.....|......:|:.|:.|||.|:|......|||.|||...||.:.:|.::..
  Rat     2 IPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSD 66

  Fly    74 ESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRF 138
            ...:..:.:.:  :.|.|:|.|:||.|:.|::.|.:.|:::...|..|::..|:..|..:|:||.
  Rat    67 PHGVSHVKLDD--LNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRM 129

  Fly   139 HPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEV 203
            ...:.:..|.||..|...:|::..|.||.::..::|:.||||.|. ...||:|..|.:.:.:...
  Rat   130 DVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLP-RLKLEVMLEDNVCLPSNGK 193

  Fly   204 IFEACMKWVK---------------------YAEDKR----------SELF-------------- 223
            ::...:.||:                     |:.|.:          :|:|
  Rat   194 LYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKP 258

  Fly   224 PQ-------------VLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLD-------------- 261
            |:             .|::....:.||:.....||.|:...:::.|..:||
  Rat   259 PRENGHKQISGSSTGCLSSPNASVQSPKHEWKIVASEKTSNNTYLCLAVLDGTFCVIFLHGRNSP 323

  Fly   262 -----------EAKDFHLMPERRGLLQ---SFRTRQRSG---EFFTGQIYAVGGLASTGESVSTV 309
                       ::..|.:.|:.  ||:   |.....|||   ....|::.|.||. :..|.:.||
  Rat   324 QSSPTSTPKLSKSLSFEMQPDE--LLEKPMSPMQYARSGLGTAEMNGKLIAAGGY-NREECLRTV 385

  Fly   310 EIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNG-TERLSTVEVYDPRKNKWSQGCAML 373
            |.|||.|..|.....|...|:|..:|||.|:||..||.|| ::.||..|:|||..:.|:....:.
  Rat   386 ECYDPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDPSIDDWTPVPELR 450

  Fly   374 CKRSAVGVAALDDCIYVCGGYD--GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVY 436
            ..|...||.||:..:|:.||.|  |...|...:|:.|.:.:|.:.|.:...|....|.:|.||:|
  Rat   451 TNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLY 515

  Fly   437 ALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYD 501
            .:||.:..:..::||||:...:.|..::||...|...|||.|:||::|.||:.|:..:..||.||
  Rat   516 IIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSHAISCVEMYD 580

  Fly   502 PQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWT 555
            |..:.||::..|...||...:......::|:||:||...|:|||||:.|:::|:
  Rat   581 PTRNEWKMMGNMTSPRSNAGITTVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	30/105 (29%)
		PHA03098	36..510	CDD:222983	155/565 (27%)
		BACK	143..245	CDD:285009	28/159 (18%)
		Kelch	292..339	CDD:128874	18/46 (39%)
		KELCH repeat	329..372	CDD:276965	19/43 (44%)
		Kelch	340..386	CDD:128874	18/46 (39%)
		KELCH repeat	376..417	CDD:276965	14/42 (33%)
		Kelch	387..433	CDD:128874	13/47 (28%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		Kelch	435..480	CDD:128874	15/44 (34%)
		Kelch_1	469..514	CDD:279660	18/44 (41%)
		KELCH repeat	470..514	CDD:276965	18/43 (42%)
		Kelch_1	517..560	CDD:279660	15/39 (38%)
		KELCH repeat	517..560	CDD:276965	15/39 (38%)
Ivns1abp	XP_006250050.1	BTB_POZ_NS1BP	14..137	CDD:349615	34/124 (27%)
		PHA03098	23..638	CDD:222983	172/618 (28%)
		BACK_NS1BP_IVNS1ABP	129..225	CDD:350577	20/96 (21%)
		KELCH repeat	358..401	CDD:276965	16/43 (37%)
		KELCH repeat	405..450	CDD:276965	19/44 (43%)
		KELCH repeat	453..498	CDD:276965	15/44 (34%)
		KELCH repeat	502..546	CDD:276965	14/43 (33%)
		KELCH repeat	549..592	CDD:276965	18/42 (43%)
		KELCH repeat	596..635	CDD:276965	15/39 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820