Protein Alignment KLHL18 and Klhl6

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_063126397.1
• Gene: Klhl6 / 287974
• RGDID: 1307521
• Length: 647
• Species: Rattus norvegicus
• Alignment Length: 593
• Identity: 187/593 - (31%)
• Similarity: 267/593 - (45%)
• Gaps: 84/593 - (14%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYF----------------------------YAMF 68
            :|....|.||.|.|:.|.||.|||||||...||                            .|||
  Rat    63 LREENALTDVILCVDIQEFSCHRVVLAAASNYFRSASRALSSTYSVSSVTGHHRDQNLFMNVAMF 127

  Fly    69 TNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASF 133
            .|::.|...|.|.:|  .::...:.:|:||.|:.:..|..||||.::..|:..|...:.||||||
  Rat   128 CNDLKEKYEKRIIIK--GVDAETMHTLLNYTYTSKALITKQNVQRVLEAANLFQFLQLVDACASF 190

  Fly   134 LISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNV 198
            |....:|.|.:||...||:.....|......||.|||.::..|||||.|..:.|..::|.|:|.|
  Rat   191 LTEALNPENCIGILRLADTHSLDSLKTQVQSYIIQNFVQILNSEEFLELPVDTLYHILRSDDLCV 255

  Fly   199 RTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEA 263
            ..|..:||..|.||::.:.:|..|.|.||..||||||.|.:..:.|..:.|||...:...||.||
  Rat   256 TEESQVFETVMSWVRHKQSERLCLLPCVLENVRLPLLDPWYFVEMVEADPLIRQCPEVFPLLQEA 320

  Fly   264 KDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMM 328
            :.:||....   :.|.||:.|..||.:.....:||.......|:.|...|||            .
  Rat   321 RMYHLSGNE---IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPL------------R 370

  Fly   329 RSRVGVA----------------------VLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCA 371
            |||:.||                      .|..::|..|   |.|....|..|:...|||.|...
  Rat   371 RSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISG---GKETQHDVWKYNSSINKWIQIEY 432

  Fly   372 MLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVY 436
            :...|....:..|...:||.||:||:..:|.||.|.|..|.|...|.::.:.|:...|.....:|
  Rat   433 LNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLY 497

  Fly   437 AL-GGHDGLSIFDSVERYDQAEDVWVKMSPM-LNRRCRLGVATLNGKIYVCGGYCGNSFLRSVEC 499
            .: ||.:|....|..:.||.:.:.||..|.| :..:| :...:....|||.||     .:|::..
  Rat   498 VIGGGPNGKLATDKTQCYDPSTNKWVLKSAMPVEAKC-INAVSFQDHIYVVGG-----AMRALYA 556

  Fly   500 YDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESN--LSTVEVYDPETDKWT---FMPP 559
            |.|..|:|.|||.::.:|:...:|....||:..||.| |.|  ::||..:|||..|.|   .:|.
  Rat   557 YSPLEDSWCLVTQLSHERASCGIAPCNNKLYITGGRD-EKNEVIATVLCWDPEAQKLTEECVLPR 620

  Fly   560 MCAHSGGV 567
            ..:|.|.|
  Rat   621 GVSHHGSV 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	44/132 (33%)
		PHA03098	36..510	CDD:222983	163/525 (31%)
		KELCH repeat	329..372	CDD:276965	16/64 (25%)
		KELCH repeat	376..417	CDD:276965	15/40 (38%)
		KELCH repeat	423..466	CDD:276965	12/43 (28%)
		KELCH repeat	470..514	CDD:276965	14/43 (33%)
		Kelch_1	517..560	CDD:396078	17/47 (36%)
		KELCH repeat	517..560	CDD:276965	17/47 (36%)
Klhl6	XP_063126397.1	None