Protein Alignment KLHL18 and KLHL35

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001034637.2
• Gene: KLHL35 / 283212
• HGNCID: 26597
• Length: 583
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 162/563 - (28%)
• Similarity: 255/563 - (45%)
• Gaps: 53/563 - (9%)

  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE--------- 88
            ||.|.|.||.|:...:.|..||..|:|...||.::|.....|.....:.:...|.|
Human    35 RRSGTLTDVVLRAGGRDFPCHRAALSAGSAYFRSLFAAGRPERGPAVVPVVPVAPEAPGTSPAGA 99

  Fly    89 PSALESLINYVYSGQVRIDNQN-VQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADS 152
            .:||..:::|||...||:..:: ...::..|..|.::.:|:||..||..|....|.|.:|..|.:
Human   100 AAALAVVLDYVYGAGVRLRAEDEAAAVLALAERLGVAGLREACVRFLEGRLRAANSLALRRVAAA 164

  Fly   153 MICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAED 217
            .....|.:...:.:.|.||:|::..:||.|..::::.|:....|.|..||.:|||.|:||::...
Human   165 FSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVVALLADPALGVAREEAVFEAAMRWVRHDAP 229

  Fly   218 KRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTR 282
            .|.....::|..||||||:|.:..::|..:||:::..:||.||.||:...::....|.|   |||
Human   230 ARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILGREAGAL---RTR 291

  Fly   283 QRSGEFFTGQIYAVGGLASTG-ESVSTVEIYDPLTKKW-KMGEQMSMMRSRVGVAVLNGKLYAFG 345
            .|........|..:||....| ..:...:.|.|.:::| .:.......||......|...:|..|
Human   292 PRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSG 356

  Fly   346 G-FNG------TERLST-VEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNT 402
            | .|.      :..|.| ::|....|.:|..           .:|.:...::..||:||:..|::
Human   357 GHINSHDVWMFSSHLHTWIKVASLHKGRWRH-----------KMAVVQGQLFAVGGFDGLRRLHS 410

  Fly   403 VEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGG--HDGLSIFDSVERYDQAEDVWVKMSP 465
            ||.|.|.||||...|.:.:..|:..|....|.::.:||  ..|::. |.|:.:|..||.|...||
Human   411 VERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNT-DKVQCFDPKEDRWSLRSP 474

  Fly   466 M-LNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTW--KLVTPMNCKRSRVALAANMG 527
            . .::|| |...:|...|||.||.....|     .|||.||.|  ..|.|...:...|.:..  |
Human   475 APFSQRC-LEAVSLEDTIYVMGGLMSKIF-----TYDPGTDVWGEAAVLPSPVESCGVTVCD--G 531

  Fly   528 KLWAIGGYD--GESNLSTVEVYDPETDKWTFMPPM--CAHSGG 566
            |:..:||.|  |||. ..|..:||.:.:....|.:  |..|.|
Human   532 KVHILGGRDDRGEST-DKVFTFDPSSGQVEVQPSLQRCTSSHG 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	32/113 (28%)
		PHA03098	36..510	CDD:222983	142/498 (29%)
		KELCH repeat	329..372	CDD:276965	12/50 (24%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		KELCH repeat	423..466	CDD:276965	13/44 (30%)
		KELCH repeat	470..514	CDD:276965	18/45 (40%)
		Kelch_1	517..560	CDD:396078	13/44 (30%)
		KELCH repeat	517..560	CDD:276965	13/44 (30%)
KLHL35	NP_001034637.2	BTB_POZ_KLHL35	18..157	CDD:349574	34/121 (28%)
		BACK	156..255	CDD:197943	31/98 (32%)
		Kelch 1	301..350		10/48 (21%)
		NanM	302..553	CDD:442289	76/271 (28%)
		KELCH repeat	340..380	CDD:276965	10/39 (26%)
		Kelch 2	352..394		10/52 (19%)
		KELCH repeat	384..428	CDD:276965	16/54 (30%)
		Kelch 3	395..441		16/45 (36%)
		KELCH repeat	431..476	CDD:276965	14/45 (31%)
		Kelch 4	443..489		15/47 (32%)
		KELCH repeat	479..519	CDD:276965	17/45 (38%)
		Kelch 5	490..531		15/47 (32%)
		KELCH repeat	521..566	CDD:276965	13/47 (28%)
		Kelch	532..577	CDD:128874	14/43 (33%)
		Kelch 6	533..579		13/42 (31%)