Protein Alignment KLHL18 and Klhl18

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001347235.1
• Gene: Klhl18 / 270201
• MGIID: 2143315
• Length: 579
• Species: Mus musculus
• Alignment Length: 575
• Identity: 306/575 - (53%)
• Similarity: 408/575 - (70%)
• Gaps: 7/575 - (1%)

  Fly     3 LSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAM 67
            :.|.::..:....:...:|....:.:.:||||.|||||||||:.|..|||||:||||:||||:||
Mouse     2 VEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAM 66

  Fly    68 FTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACAS 132
            |||:|.|.:..||.|:  .::|||||:|||:.|:|.:.||.||||:|::|||||||.:::|||.:
Mouse    67 FTNDMMECKQDEIVMQ--GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCT 129

  Fly   133 FLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELN 197
            ||..|.||.|.||:|.||::|:|..|.|||:.:|.|:|.:||.|||||||..|.:|||:.|||||
Mouse   130 FLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELN 194

  Fly   198 VRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDE 262
            |::||.:|||.:.||:|..::|....|::|:.:||||..||||:|||.:::|:|..|:||||:||
Mouse   195 VKSEEQVFEAALAWVRYDREQRGPCLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDE 259

  Fly   263 AKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLAS-----TGESVSTVEIYDPLTKKWKMG 322
            |||:|||||||..|.:||||.|......|.|||||||.|     .|:|::.||::||:..:|:..
Mouse   260 AKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPIANRWEKC 324

  Fly   323 EQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDC 387
            ..|:..||||||||:||.|||.||::|..||||||.|:|..:.|::..:|..||||:|...||..
Mouse   325 HPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQ 389

  Fly   388 IYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVER 452
            |||||||||.:|||:||.|.|:::.|..|..|...|||.|||...|.:|..||||||.||.|||.
Mouse   390 IYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEH 454

  Fly   453 YDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKR 517
            |:.....|...:.|||:|||.|.|:|..|::|||||.|:.||...|.|....|.|.|:.||:.:|
Mouse   455 YNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRR 519

  Fly   518 SRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVI 572
            |||:|.|:.|:|:|:|||||:||||:||:||||||:||||.||..|.||||.|.|
Mouse   520 SRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDRWTFMAPMACHEGGVGVGCI 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	67/116 (58%)
		PHA03098	36..510	CDD:222983	258/478 (54%)
		KELCH repeat	329..372	CDD:276965	25/42 (60%)
		KELCH repeat	376..417	CDD:276965	23/40 (58%)
		KELCH repeat	423..466	CDD:276965	21/42 (50%)
		KELCH repeat	470..514	CDD:276965	21/43 (49%)
		Kelch_1	517..560	CDD:396078	30/42 (71%)
		KELCH repeat	517..560	CDD:276965	30/42 (71%)
Klhl18	NP_001347235.1	BTB_POZ_KLHL18	19..134	CDD:349556	67/116 (58%)
		PHA03098	34..557	CDD:222983	287/524 (55%)
		BACK_KLHL18	135..241	CDD:350532	56/105 (53%)
		KELCH repeat	282..327	CDD:276965	16/44 (36%)
		KELCH repeat	331..374	CDD:276965	25/42 (60%)
		Kelch 2. /evidence=ECO:0000255	342..388		22/45 (49%)
		KELCH repeat	378..422	CDD:276965	24/43 (56%)
		Kelch 3. /evidence=ECO:0000255	389..435		25/45 (56%)
		KELCH repeat	425..469	CDD:276965	21/43 (49%)
		Kelch 4. /evidence=ECO:0000255	437..482		23/44 (52%)
		KELCH repeat	472..516	CDD:276965	21/43 (49%)
		Kelch 5. /evidence=ECO:0000255	484..529		21/44 (48%)
		KELCH repeat	519..562	CDD:276965	30/42 (71%)
		Kelch 6. /evidence=ECO:0000255	530..576		32/45 (71%)