DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Klhl38

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_808423.1	Gene:	Klhl38 / 268807	MGIID:	3045310	Length:	581	Species:	Mus musculus

Alignment Length:	555	Identity:	162/555 - (29%)
Similarity:	249/555 - (44%)	Gaps:	73/555 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKE 79
            |:|......:.......:|:...|.||::.........||.|||::.|||.|||.::..|||..:
Mouse    10 VFKDHSFSSDLLRQLNGLRQSKILTDVSICSGAWEVPCHRSVLASSSPYFKAMFCSHFRESREAK 74

  Fly    80 ITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVL 144
            :.||  .|..:.||.:|.|||:|:|.|...||..||..|:.||...|.:||:|:|.|:..|.|.|
Mouse    75 VQMK--GISSTTLEQVITYVYTGEVHISAANVLPLMEAAAMLQYPRVFEACSSYLQSQLAPSNCL 137

  Fly   145 GIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACM 209
            |:...|:.:.|..|...|.:.....|.:|:.|.:...|...:|.:.:..|.| ...||.:|||.|
Mouse   138 GLVRLAEILSCDSLKKKAKEVALTYFPEVAASADLKELCAMELRDYLGDDRL-CGEEEKVFEALM 201

  Fly   210 KWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLD------------E 262
            .|||:....|.....::|..|||..:.|.|....:|.:.|::||..|:.:|:            .
Mouse   202 AWVKHDLQARWRHMQELLQQVRLQYIHPAFFHHFIANDALLQSSPACQAILEMARKQIFSLYGPS 266

  Fly   263 AKDFHL---MPERRG------LLQSFRTRQR--------SGEFFTGQ------------------ 292
            |:|..|   ||.|..      ||...:..|:        ||:  |||
Mouse   267 AQDCKLLWRMPPRSSYQDFLLLLGGRKDNQQTTRDVLLYSGQ--TGQWQSLAKLPIRLYKASAVT 329

  Fly   293 ----IYAVGGL-ASTGESVST--VEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGF-NG 349
                :|.:||: .|.|:|:.:  |.|:.....:|::||.|...|...........:::.||. .|
Mouse   330 LHRSVYVLGGMTVSEGKSLISCGVYIFSLKLNQWRVGEPMLAARYSHRSTTHRNFIFSIGGTGEG 394

  Fly   350 TERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS-LNTVEVYYPKSNTW 413
            .|.|:::|.||..::.|.....|........||..|..:|:.||.|.:.: :..::||:...|||
Mouse   395 QELLASMERYDSIRDVWESMAGMPVAVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNTW 459

  Fly   414 -KTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVAT 477
             |...:|:|...|..|. |...:..:||:.     ..:..||...:.:||.:.|.:||...|...
Mouse   460 YKMETRMIKNVCAPAVV-LGEQIVIVGGYT-----RRILAYDPQSNKFVKCADMKDRRMHHGATV 518

  Fly   478 LNGKIYVCGGY-----CGNSFLRSVECYDPQTDTW 507
            :..|:||.||.     |......|.:||||:||||
Mouse   519 MGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTW 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	41/105 (39%)
		PHA03098	36..510	CDD:222983	159/534 (30%)
		BACK	143..245	CDD:285009	29/101 (29%)
		Kelch	292..339	CDD:128874	14/71 (20%)
		KELCH repeat	329..372	CDD:276965	10/43 (23%)
		Kelch	340..386	CDD:128874	12/46 (26%)
		KELCH repeat	376..417	CDD:276965	13/42 (31%)
		Kelch	387..433	CDD:128874	15/47 (32%)
		KELCH repeat	423..466	CDD:276965	9/42 (21%)
		Kelch	435..480	CDD:128874	10/44 (23%)
		Kelch_1	469..514	CDD:279660	18/44 (41%)
		KELCH repeat	470..514	CDD:276965	17/43 (40%)
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
Klhl38	NP_808423.1	BTB	24..128	CDD:279045	41/105 (39%)
		PHA03098	48..560	CDD:222983	156/517 (30%)
		BACK	136..237	CDD:285009	29/101 (29%)
		Kelch_6	281..321	CDD:290672	8/41 (20%)
		Kelch 1	285..332		8/48 (17%)
		KELCH repeat	325..369	CDD:276965	11/43 (26%)
		Kelch	334..383	CDD:128874	13/48 (27%)
		Kelch 2	334..383		13/48 (27%)
		KELCH repeat	373..417	CDD:276965	10/43 (23%)
		Kelch 3	384..431		12/46 (26%)
		Kelch	385..428	CDD:128874	11/42 (26%)
		KELCH repeat	421..508	CDD:276965	24/92 (26%)
		Kelch 4	433..479		15/46 (33%)
		Kelch	480..521	CDD:128874	10/45 (22%)
		Kelch 5	480..521		10/45 (22%)
		Kelch_1	510..560	CDD:279660	18/44 (41%)
		KELCH repeat	511..561	CDD:276965	17/43 (40%)
		Kelch 6	523..573		14/31 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900