Protein Alignment KLHL18 and Klhl31

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_766513.2
• Gene: Klhl31 / 244923
• MGIID: 3045305
• Length: 634
• Species: Mus musculus
• Alignment Length: 571
• Identity: 160/571 - (28%)
• Similarity: 272/571 - (47%)
• Gaps: 41/571 - (7%)

  Fly     2 DLSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYA 66
            :|:|.|        |..:.|.|.|     ::|:...|||:.:..:.::|..|:.|:|:...|||.
Mouse    49 ELTDTS--------YGPNLLEGLS-----KMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYN 100

  Fly    67 MFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACA 131
            :..|:.:..|:     ..:.|.|..|.::|.|.|:|::.:....:.:::..|.:||:..:...|:
Mouse   101 ILKNDPSTKRV-----DLNDIAPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCS 160

  Fly   132 SFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDEL 196
            .|||......|.:.:...|::...:.....|.|:|..||.:.::||:|:.|..||:.||:..|:|
Mouse   161 DFLIREISVENCMYVVNIAETYSLKNAKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDL 225

  Fly   197 NVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLD 261
            .:.:|.|.|:..|||::: :.||.:....:|:.:|...:|.|.|.:.|.....:.....|..||.
Mouse   226 QLPSELVAFQIAMKWLEF-DQKRVKHAADLLSNIRFGTISAQDLVNYVQTVPRMMQDADCHKLLV 289

  Fly   262 EAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLAS-TGESVSTVEIYDPLTKKWKMGEQM 325
            :|.::||:|..:..|||.|||.|.|   ...:..|||... |.:|:|...:|......|....:|
Mouse   290 DAMNYHLLPYHQNTLQSRRTRIRGG---CRVLITVGGRPGLTEKSLSRDILYRDPENGWSKLTEM 351

  Fly   326 SMMRSRVGVAVLNGKLYAFGGFNGTE-------RLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAA 383
            ........|||::|.||..||.:..:       .:|....||||.|.|....:|..||:...::.
Mouse   352 PAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLGSMNQKRTHFSLSV 416

  Fly   384 LDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFD 448
            .:..:|..||.:...||.::|.|.|.:|.|:..|.:...|........:|.|...||:.|.:...
Mouse   417 FNGLLYAVGGRNSEGSLASLECYVPSTNQWQPKAPLEVARCCHASAVADGRVIVTGGYIGSAYSR 481

  Fly   449 SVERYDQAEDVWVKMSPMLN--RRCRLGVATLNGKIYVCGG-YCGNSFLR----SVECYDPQTDT 506
            ||..||.|.|.|.:: |.|:  |.....|| |..::||.|| ..|....|    :||.:.|....
Mouse   482 SVCAYDPALDAWQEL-PQLSTPRGWHCAVA-LGDRLYVMGGSQLGPRGERVDVLTVESFSPAARQ 544

  Fly   507 WKLVTPMNCKRSRVALAANMGKLWAIGGY-DGESNL-STVEVYDPETDKWT 555
            |..|.|:....|...::|..|:.:.:||: :||... ..::.::||.::||
Mouse   545 WSFVAPLPVGVSTAGVSALHGRAYLLGGWNEGEKKYKKCIQCFNPELNEWT 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	30/116 (26%)
		PHA03098	36..510	CDD:222983	139/488 (28%)
		KELCH repeat	329..372	CDD:276965	15/49 (31%)
		KELCH repeat	376..417	CDD:276965	11/40 (28%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		KELCH repeat	470..514	CDD:276965	15/48 (31%)
		Kelch_1	517..560	CDD:396078	11/41 (27%)
		KELCH repeat	517..560	CDD:276965	11/41 (27%)
Klhl31	NP_766513.2	BTB_POZ_KLHL31_KBTBD1	55..174	CDD:349569	32/128 (25%)
		PHA03098	73..601	CDD:222983	151/534 (28%)
		BACK	167..264	CDD:475122	27/97 (28%)
		Kelch 1	317..365		12/47 (26%)
		KELCH repeat	356..405	CDD:276965	15/48 (31%)
		Kelch 2	366..419		14/52 (27%)
		KELCH repeat	409..453	CDD:276965	12/43 (28%)
		Kelch 3	420..466		12/45 (27%)
		KELCH repeat	456..501	CDD:276965	15/45 (33%)
		Kelch 4	468..513		17/46 (37%)
		KELCH repeat	503..553	CDD:276965	16/50 (32%)
		Kelch 5	515..565		14/49 (29%)
		KELCH repeat	555..602	CDD:276965	11/41 (27%)
		Kelch 6	566..614		8/30 (27%)