DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Kbtbd8

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001008785.2	Gene:	Kbtbd8 / 243574	MGIID:	2661430	Length:	599	Species:	Mus musculus

Alignment Length:	566	Identity:	150/566 - (26%)
Similarity:	249/566 - (43%)	Gaps:	130/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFKEIRRM---GKLCDVTLKVE-DQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE 88
            :.|:::.|   |:|.|:.::|: .:|||.||.||||..|||.:|||:.:.||..||:.:  ..:|
Mouse    35 ILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI--IGVE 97

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            ..:::.::||.|:.:|.:...|||.|...||..|:.:::|.||.::||...|.|.:|:..|||..
Mouse    98 AESMDLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHY 162

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDK 218
            ..::|.|.:.:||.:.|..|::.:|||.|..:||:.::..|:|||..||.::|:.::|.::.:.:
Mouse   163 GHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQSE 227

  Fly   219 RSELFPQVLA-AVRLPLLS--------PQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRG 274
            |....|::.| .:|.||:.        |||      .:.:::|   |.:           |.
Mouse   228 REVHLPEIFAKCIRFPLMEDTFIEKIPPQF------AQAIVKS---CGE-----------PS--- 269

  Fly   275 LLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNG 339
              .:....||.|...:..|..............||...|                      ::.|
Mouse   270 --NTSGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLD----------------------IVTG 310

  Fly   340 KLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCK----RSAVGV-AALDDCIYVCGGYDGVTS 399
            :::                             .|||    ...||: .:.|:.||:.|||...:|
Mouse   311 RVF-----------------------------KLCKPPNDLREVGILVSPDNDIYIAGGYRPSSS 346

  Fly   400 LNTVE--------VYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGH----DGLSIFDSVER 452
            ..:::        :|...:|.|.:...:::.|....:....|.:||:||.    ||.:...|||.
Mouse   347 EVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVEC 411

  Fly   453 YDQAEDVWVKMSPMLNRRCRLGVA-------TLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLV 510
            ||..|:.|:.:       |.:.||       ....||||..   |..||    .|:||.|.|..:
Mouse   412 YDSRENCWMTV-------CAMPVAMEFHNAVEHKEKIYVLQ---GEFFL----FYEPQKDYWGFL 462

  Fly   511 TPMNCKRSRVALAANMGKLWAIGGYDG-ESNLSTVEVYDPETDKWT 555
            |||...|.:...|.....::.|.|..| ...:.|||.||.|.:|||
Mouse   463 TPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRVFTVEAYDIELNKWT 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	40/109 (37%)
		PHA03098	36..510	CDD:222983	131/507 (26%)
		BACK	143..245	CDD:285009	33/110 (30%)
		Kelch	292..339	CDD:128874	4/46 (9%)
		KELCH repeat	329..372	CDD:276965	1/42 (2%)
		Kelch	340..386	CDD:128874	5/50 (10%)
		KELCH repeat	376..417	CDD:276965	12/49 (24%)
		Kelch	387..433	CDD:128874	10/53 (19%)
		KELCH repeat	423..466	CDD:276965	15/46 (33%)
		Kelch	435..480	CDD:128874	16/55 (29%)
		Kelch_1	469..514	CDD:279660	17/51 (33%)
		KELCH repeat	470..514	CDD:276965	17/50 (34%)
		Kelch_1	517..560	CDD:279660	14/40 (35%)
		KELCH repeat	517..560	CDD:276965	14/40 (35%)
Kbtbd8	NP_001008785.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		BTB	39..144	CDD:279045	39/106 (37%)
		PHA03098	50..514	CDD:222983	146/551 (26%)
		BACK	153..250	CDD:285009	30/96 (31%)
		KELCH repeat	328..374	CDD:276965	10/45 (22%)
		Kelch 1	334..388		10/53 (19%)
		Kelch	335..386	CDD:128874	10/50 (20%)
		Kelch_1	377..426	CDD:279660	16/55 (29%)
		KELCH repeat	378..426	CDD:276965	16/54 (30%)
		Kelch 2	389..439		16/56 (29%)
		KELCH repeat	429..465	CDD:276965	13/42 (31%)
		Kelch 3	441..479		16/44 (36%)
		Kelch_1	468..514	CDD:279660	14/41 (34%)
		Kelch 4	481..530		12/28 (43%)
		KELCH repeat	517..569	CDD:276965
		Kelch 5	540..586
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810