Protein Alignment KLHL18 and Klhl21

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001028524.1
• Gene: Klhl21 / 242785
• MGIID: 1919288
• Length: 597
• Species: Mus musculus
• Alignment Length: 607
• Identity: 170/607 - (28%)
• Similarity: 249/607 - (41%)
• Gaps: 130/607 - (21%)

  Fly    31 EIRRMGKLCDVTLKVE-DQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALES 94
            ::|...|..||||:.. .:.|.|||.||||..|||.|||...:.|||.:.:.:  ..:.|..|:.
Mouse    27 QLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRL--HGVPPDMLQL 89

  Fly    95 LINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLI 159
            |:::.|:|:|.:...|.:.|:..|..||...|::||.:||..:....|.|.::.||::..|..|.
Mouse    90 LLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLA 154

  Fly   160 DAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFP 224
            .||.::|.::..::. :|:...|...:||..:|.|.|.|..||..::..::||:....:|:..:|
Mouse   155 SAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAPHWP 218

  Fly   225 QVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLM---PERRGLLQSFRTRQRSG 286
            |:|.|||||.:...:|...|..|.|:.....|..||.||:||...   ...||.....|.|..:|
Mouse   219 QLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTG 283

  Fly   287 EFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTE 351
              ....:..|||.....:.:.||:.|:|.|.:|:   .::.....:|           ||::
Mouse   284 --LAEILVLVGGCDQDCDELVTVDCYNPQTGQWR---YLAEFPDHLG-----------GGYS--- 329

  Fly   352 RLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTV 416
                                         :.||.:.|||.||.||....:.|..|....|.|..|
Mouse   330 -----------------------------IVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEV 365

  Fly   417 AQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGK 481
            |.|:|.|.....:.|:|.:|.:..       ||.||||.|.|.|..:.||.............|:
Mouse   366 APMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHATDSWEALQPMTYPMDNCSTTACRGR 423

  Fly   482 IYVCGGYCGNSFLRSVECYDPQTDTWKLVT----------------------------------- 511
            :|..|...|...: .::||||.||.|.||.
Mouse   424 LYAIGSLAGKETM-VIQCYDPDTDLWSLVNCGQLPPWSFAPKTVTLNGLMYFVRDDSAEVDVYNP 487

  Fly   512 ---------PMNCKRSRVALAANMGKLWAIGGYDGESNLS-TVEVYDPETDKWT----------- 555
                     .||......:||...|||:..||||....|| .||.|||||..|:
Mouse   488 TKDEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFW 552

  Fly   556 ---------FMPPMCAHSGGVG 568
                     |||...|  ||.|
Mouse   553 HGSVSIFRQFMPQTPA--GGRG 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	39/106 (37%)
		PHA03098	36..510	CDD:222983	139/477 (29%)
		KELCH repeat	329..372	CDD:276965	3/42 (7%)
		KELCH repeat	376..417	CDD:276965	13/40 (33%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		KELCH repeat	470..514	CDD:276965	13/87 (15%)
		Kelch_1	517..560	CDD:396078	22/63 (35%)
		KELCH repeat	517..560	CDD:276965	22/63 (35%)
Klhl21	NP_001028524.1	BTB_POZ_KLHL21	14..138	CDD:349559	39/112 (35%)
		PHA03098	49..547	CDD:222983	156/556 (28%)
		BACK_KLHL21	133..232	CDD:350535	30/99 (30%)
		Kelch 1	287..335		14/93 (15%)
		KELCH repeat	326..368	CDD:276965	17/73 (23%)
		Kelch 2	336..382		17/45 (38%)
		KELCH repeat	372..409	CDD:276965	14/43 (33%)
		Kelch 3	384..422		12/44 (27%)
		KELCH repeat	412..451	CDD:276965	11/39 (28%)
		Kelch 4	423..470		12/47 (26%)
		Kelch 5	472..512		4/39 (10%)
		KELCH repeat	502..548	CDD:276965	19/45 (42%)
		Kelch 6	513..560		16/46 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..597		2/3 (67%)