DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and Klhl6

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_899246.2	Gene:	Klhl6 / 239743	MGIID:	2686922	Length:	619	Species:	Mus musculus

Alignment Length:	565	Identity:	186/565 - (32%)
Similarity:	265/565 - (46%)	Gaps:	56/565 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|....|.||.|.|:.|.||.|||||||...||.|||.|::.|...|.|.:|  .::...:.:|:
Mouse    63 LREENALTDVILCVDVQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIK--GVDAETMHTLL 125

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            .|.|:.:..|..||||.::..|:..|...:.|||||||....:|.|.:||...||:.....|...
Mouse   126 VYTYTSKALITKQNVQRVLEAANLFQFLQLVDACASFLTEALNPENCIGILRLADTHSLDSLKMQ 190

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            ...||.|||.::..|||||.|..:.|..::|.|:|.|..|..:||..|.||::.:.:|..|.|.|
Mouse   191 VQSYIIQNFVQILNSEEFLELPVDTLYHILRSDDLCVTEEAQVFETVMSWVRHKQSERLCLLPCV 255

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTG 291
            |..||||||.|.:..:.|..:.|||...:...||.||:.:||....   :.|.||:.|..||.:.
Mouse   256 LENVRLPLLDPWYFVEMVEADPLIRQCPEVFPLLQEARMYHLSGNE---IISERTKPRMHEFQSE 317

  Fly   292 QIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVA--------------------- 335
            ....:||.......|:.|...|||            .|||:.||
Mouse   318 VFMIIGGCTKDERFVAEVTCLDPL------------RRSRLEVAKLPLTEHELESENKKWVEFAC 370

  Fly   336 -VLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS 399
             .|..::|..|   |.|....|..|:...|||.|...:...|....:..|...:||.||:||:..
Mouse   371 VTLKNEVYISG---GKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVLGGFDGLQR 432

  Fly   400 LNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYAL-GGHDGLSIFDSVERYDQAEDVWVKM 463
            :|.||.|.|..|.|...|.:..:.|:...|.....:|.: ||.:|....|..:.||.:.:.||..
Mouse   433 INNVETYDPFHNCWSEAAPLHVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWVLK 497

  Fly   464 SPM-LNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMG 527
            |.| :..:| :...:....|||.||     .:|::..|.|..|:|.|||.::.:|:...:|....
Mouse   498 SAMPVEAKC-INAVSFQDHIYVVGG-----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNN 556

  Fly   528 KLWAIGGYDGESN--LSTVEVYDPETDKWT---FMPPMCAHSGGV 567
            ||:..||.| |.|  ::||..:|||..|.|   .:|...:|.|.|
Mouse   557 KLYITGGRD-EKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSV 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	42/102 (41%)
		PHA03098	36..510	CDD:222983	162/497 (33%)
		BACK	143..245	CDD:285009	39/101 (39%)
		Kelch	292..339	CDD:128874	13/68 (19%)
		KELCH repeat	329..372	CDD:276965	16/64 (25%)
		Kelch	340..386	CDD:128874	12/45 (27%)
		KELCH repeat	376..417	CDD:276965	15/40 (38%)
		Kelch	387..433	CDD:128874	16/45 (36%)
		KELCH repeat	423..466	CDD:276965	12/43 (28%)
		Kelch	435..480	CDD:128874	12/46 (26%)
		Kelch_1	469..514	CDD:279660	14/44 (32%)
		KELCH repeat	470..514	CDD:276965	14/43 (33%)
		Kelch_1	517..560	CDD:279660	17/47 (36%)
		KELCH repeat	517..560	CDD:276965	17/47 (36%)
Klhl6	NP_899246.2	BTB	60..163	CDD:279045	41/101 (41%)
		BTB	71..163	CDD:197585	39/93 (42%)
		BACK	172..274	CDD:285009	39/101 (39%)
		Kelch 1	318..365		12/58 (21%)
		KELCH repeat	368..405	CDD:276965	11/39 (28%)
		Kelch 2	376..419		12/45 (27%)
		KELCH repeat	409..453	CDD:276965	16/43 (37%)
		Kelch	420..466	CDD:128874	16/45 (36%)
		Kelch 3	420..466		16/45 (36%)
		KELCH repeat	456..502	CDD:276965	13/45 (29%)
		Kelch_1	457..501	CDD:279660	12/43 (28%)
		Kelch 4	468..514		12/46 (26%)
		KELCH repeat	504..544	CDD:276965	14/45 (31%)
		Kelch	515..556	CDD:128874	15/45 (33%)
		Kelch 5	515..556		15/45 (33%)
		KELCH repeat	546..591	CDD:276965	16/45 (36%)
		Kelch_1	546..583	CDD:279660	14/37 (38%)
		Kelch 6	558..604		17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810