DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and Klhl36

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_666331.1 Gene:Klhl36 / 234796 MGIID:2385305 Length:613 Species:Mus musculus


Alignment Length:603 Identity:165/603 - (27%)
Similarity:278/603 - (46%) Gaps:45/603 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDLSDNSQVEDQYFVYKHDKLFGESFP--------LFKEIRRMGKLCDVTLKVEDQTFSAHRVVL 57
            |:.|...:|...|.:.:..|::  .:|        ...|.|..|..|||.|.||:|...|||.:|
Mouse     1 MEASKQMRVSRPYKISESSKVY--HWPDHSTAVLQRLNEQRLHGLFCDVVLVVEEQQVPAHRNLL 63

  Fly    58 AATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQ 122
            |....||.:|||..|.|:..||:.:..::.  ..|:::::::||.::.:|..|:..::..|..||
Mouse    64 AVCSDYFNSMFTLGMREAFQKEVELVGTSY--VGLKAVVDFLYSSELELDGSNIDYILETAHLLQ 126

  Fly   123 LSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFL-ALDCEQ 186
            :..|.|.|..:|.......|.|.::..|.....::|....|.::..:|:.:|.:.:|| ::..::
Mouse   127 IWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDSFVLSHFSTLSFTPDFLQSISVQK 191

  Fly   187 LLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRV--AREEL 249
            |...:...::..:.|..:.:..::|:. .:.:|.....:||..:|.||.....|..||  |...|
Mouse   192 LCVYLSSGQVQHKWEYDLLQVALQWLT-QQPEREVHTRRVLENIRFPLFPEDILLQRVKLAMCSL 255

  Fly   250 IRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGE--FFTGQIYAVGGLASTGESVSTVEIY 312
            :.|.......::||..:|.....:.:||:.||..||.|  .|.|     |.::.....:|....|
Mouse   256 LPSEANGEGFVEEAMHYHNSLVAQPVLQTKRTLLRSEECLLFVG-----GEVSERCLELSDDTCY 315

  Fly   313 -DPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGF----NGTERLSTVEV-YDPRKNKWSQGCA 371
             |...::|.....:...||...||||.|.::..||.    ||....|.:.. ||||:.:|.:..:
Mouse   316 LDTKNEQWVKETSLPARRSHHCVAVLGGFIFIAGGSFSRDNGGNAASNLLYRYDPRRKQWIKVAS 380

  Fly   372 MLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVY 436
            |..:|....:|:::|.:...||.:...:|::||.|.||:|:|..||.:.::......|....:||
Mouse   381 MNQRRVDFYLASIEDMLVAVGGRNENGALSSVETYSPKTNSWTYVAGLPRFTYGHAGTIYKDFVY 445

  Fly   437 ALGGHD---GLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRS-- 496
            ..||||   | ....::..||...|||.:..||...|....:.:|...||..||  .:..:.|  
Mouse   446 ISGGHDYQIG-PYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGG--SDDHMESME 507

  Fly   497 ------VECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNL--STVEVYDPETDK 553
                  ||.|.||.:.|..|.|:....|...:|...|:::.:|||..||..  ..|:|||.|.::
Mouse   508 RFDVLGVEAYSPQCNQWTRVAPLLQANSESGVAVWQGRIYILGGYSWESTAFSRAVQVYDSEANR 572

  Fly   554 WTFMPPMCAHSGGVGAGV 571
            |:..|.:.....||.|.|
Mouse   573 WSRGPDLPNAIAGVSACV 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 38/124 (31%)
PHA03098 36..510 CDD:222983 136/495 (27%)
KELCH repeat 329..372 CDD:276965 17/47 (36%)
KELCH repeat 376..417 CDD:276965 13/40 (33%)
KELCH repeat 423..466 CDD:276965 13/45 (29%)
KELCH repeat 470..514 CDD:276965 15/51 (29%)
Kelch_1 517..560 CDD:396078 15/44 (34%)
KELCH repeat 517..560 CDD:276965 15/44 (34%)
Klhl36NP_666331.1 BTB_POZ 20..154 CDD:453885 40/137 (29%)
BACK 142..240 CDD:475122 18/98 (18%)
Kelch 1 294..343 13/53 (25%)
NanM 322..590 CDD:442289 82/270 (30%)
KELCH repeat 333..381 CDD:276965 17/47 (36%)
Kelch 2 344..395 13/50 (26%)
KELCH repeat 385..429 CDD:276965 15/43 (35%)
Kelch 3 396..442 13/45 (29%)
KELCH repeat 432..479 CDD:276965 15/47 (32%)
Kelch 4 444..491 16/47 (34%)
KELCH repeat 481..531 CDD:276965 15/51 (29%)
Kelch 5 492..544 15/53 (28%)
KELCH repeat 534..580 CDD:276965 15/45 (33%)
Kelch 6 545..593 16/46 (35%)

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