Protein Alignment KLHL18 and KLHL18

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_005265058.2
• Gene: KLHL18 / 23276
• HGNCID: 29120
• Length: 584
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 305/580 - (52%)
• Similarity: 406/580 - (70%)
• Gaps: 12/580 - (2%)

  Fly     3 LSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAM 67
            :.|.::..:....:...:|....:.:.:||||.|||||||||:.|..|||||:||||:||||:||
Human     2 VEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAM 66

  Fly    68 FTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACAS 132
            |||:|.|.:..||.|:  .::|||||:|||:.|:|.:.||.||||:|::|||||||.:::|||.:
Human    67 FTNDMMECKQDEIVMQ--GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCT 129

  Fly   133 FLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELN 197
            ||..|.||.|.||:|.||::|:|..|.|||:.:|.|:|.:||.|||||||..|.:|||:.|||||
Human   130 FLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELN 194

  Fly   198 VRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDE 262
            |::||.:|||.:.||:|..::|....|::|:.:||||..||||:|||.:::|:|..|:||||:||
Human   195 VKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDE 259

  Fly   263 AKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLAS-----TGESVSTVEIYDPLTKKWKMG 322
            |||:|||||||..|.:||||.|......|.|||||||.|     .|:|::.||::||:...|:..
Human   260 AKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPIANCWERC 324

  Fly   323 EQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKR-----SAVGVA 382
            ..|:..||||||||:||.|||.||::|..||||||.|:|..:.|::..:|..||     ||:|..
Human   325 RPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSSVCFSAMGTV 389

  Fly   383 ALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIF 447
            .||..|||||||||.:||::||.|.|:::.|..|..|...|||.|||...|.:|..||||||.||
Human   390 VLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIF 454

  Fly   448 DSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTP 512
            .|||.|:.....|...:.|||:|||.|.|:|..|::|||||.|:.||...|.|....|.|.|:.|
Human   455 SSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVP 519

  Fly   513 MNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVI 572
            |:.:||||:|.|:.|:|:|:|||||:||||:||:||||||.||||.||..|.||||.|.|
Human   520 MHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGVGCI 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	67/116 (58%)
		PHA03098	36..510	CDD:222983	257/483 (53%)
		KELCH repeat	329..372	CDD:276965	25/42 (60%)
		KELCH repeat	376..417	CDD:276965	22/45 (49%)
		KELCH repeat	423..466	CDD:276965	21/42 (50%)
		KELCH repeat	470..514	CDD:276965	21/43 (49%)
		Kelch_1	517..560	CDD:396078	30/42 (71%)
		KELCH repeat	517..560	CDD:276965	30/42 (71%)
KLHL18	XP_005265058.2	BTB_POZ_KLHL18	19..134	CDD:349556	66/114 (58%)
		PHA03098	34..562	CDD:222983	292/537 (54%)
		BACK_KLHL18	135..241	CDD:350532	56/105 (53%)
		KELCH repeat	282..327	CDD:276965	18/49 (37%)
		KELCH repeat	331..374	CDD:276965	23/42 (55%)
		KELCH repeat	378..427	CDD:276965	24/48 (50%)
		KELCH repeat	430..474	CDD:276965	21/43 (49%)
		KELCH repeat	477..521	CDD:276965	21/43 (49%)
		KELCH repeat	524..567	CDD:276965	29/42 (69%)