Protein Alignment KLHL18 and Klhl41

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001074556.1
• Gene: Klhl41 / 228003
• MGIID: 2683854
• Length: 606
• Species: Mus musculus
• Alignment Length: 587
• Identity: 155/587 - (26%)
• Similarity: 274/587 - (46%)
• Gaps: 54/587 - (9%)

  Fly    30 KEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALES 94
            |::....|..|.|||..|::|..||::|:|..|||...|.:.:.|.:.||:.:..  ::|:.|:.
Mouse    24 KDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEKKKEVALDN--VDPAILDL 86

  Fly    95 LINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLI 159
            :|.|:||..:.:::.|||::...:|..|:.:|...|.|:|..|..|.|.|.|......:.|.:|.
Mouse    87 IIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLA 151

  Fly   160 DAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFP 224
            .:|.:::...|.::.:.|:|:.|..::|:.::..|.|||..|||:|||.||||:..::.|::...
Mouse   152 ISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLS 216

  Fly   225 QVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHL--MP------ERRG------- 274
            :|...:|..|::.::..|.|.::::|:|:.:.:..:...||...  :|      |:.|
Mouse   217 EVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKNAEKAGAGEVNGD 281

  Fly   275 -----LLQSF-RTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKK---WKMGEQMSMMRS 330
                 ||..: ....|.|.|....|..|...|:..        |||:..:   ..:.||:.  |:
Mouse   282 VGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVA--------YDPMENECYLTALAEQIP--RN 336

  Fly   331 RVGVAVLNGKLYAFGGFNGTE--RLSTVEVY----DPRKNKWSQGCAMLCKRSAVGVAALDDCIY 389
            ...:.....::|..||....|  :...::.|    |...::|.....:...|...|:..:||.||
Mouse   337 HSSLVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVTSEWVGLPPLPSARCLFGLGEVDDKIY 401

  Fly   390 VCGGYDGVT--SLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGH-DGLSIFDSVE 451
            |..|.|..|  ||::|..|.|.:..|..|..:........|...||.:|.|||. |.....:.|.
Mouse   402 VVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVF 466

  Fly   452 RYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCK 516
            .|:..:..|..::||...|...|||...|||.:.||...:....|||.:|.:|:.|:::|....:
Mouse   467 IYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQE 531

  Fly   517 RSRVALAANMGKLWAIGGYD---------GESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVI 572
            ||.::|.:..|.|:||||:.         ..:.::.:..|:.:..:|..|.....::.|......
Mouse   532 RSSISLVSLAGALYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLAT 596

  Fly   573 RI 574
            |:
Mouse   597 RL 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	34/106 (32%)
		PHA03098	36..510	CDD:222983	139/506 (27%)
		KELCH repeat	329..372	CDD:276965	8/48 (17%)
		KELCH repeat	376..417	CDD:276965	16/42 (38%)
		KELCH repeat	423..466	CDD:276965	11/43 (26%)
		KELCH repeat	470..514	CDD:276965	16/43 (37%)
		Kelch_1	517..560	CDD:396078	12/51 (24%)
		KELCH repeat	517..560	CDD:276965	12/51 (24%)
Klhl41	NP_001074556.1	BTB_POZ_KLHL41_KBTBD10	6..135	CDD:349650	36/112 (32%)
		PHA03098	39..578	CDD:222983	145/550 (26%)
		KELCH repeat	335..384	CDD:276965	8/48 (17%)
		Kelch 1	346..398		9/51 (18%)
		KELCH repeat	388..433	CDD:276965	17/44 (39%)
		Kelch 2	399..447		14/47 (30%)
		KELCH repeat	437..482	CDD:276965	12/44 (27%)
		Kelch 3	448..495		14/46 (30%)
		KELCH repeat	485..530	CDD:276965	16/44 (36%)
		Kelch 4	497..542		13/44 (30%)
		Kelch 5	544..599		10/55 (18%)