Protein Alignment KLHL18 and Klhl22

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001365953.1
• Gene: Klhl22 / 224023
• MGIID: 1337995
• Length: 653
• Species: Mus musculus
• Alignment Length: 569
• Identity: 158/569 - (27%)
• Similarity: 256/569 - (44%)
• Gaps: 44/569 - (7%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|..|.|.||.|.||.:...|||::|||:..||..||...:.|...:|:.:  ..:..:|:..::
Mouse    62 LRDSGILFDVVLVVEGKHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLI--HGVSYNAMCQIL 124

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            :::|:.::.:...|||..:|.|..||:..:...|..||:|.....|:|.:...||......|...
Mouse   125 HFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLADLFDLNHLTQQ 189

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELF--- 223
            .|.||.:||...|:::::..|..|::..|:..:.|.|..|..::|..:.:....|..:::..
Mouse   190 LDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLN 254

  Fly   224 --PQVLAAVRLPLLSP---QFLADRVAREELIRSSHQCRDLLDEAKDFH----LMPERRGLLQSF 279
              |::|..||.||:..   |.|.|::....|       ||.:..|..:|    |.|.    ||..
Mouse   255 EPPKLLETVRFPLMEAEVLQRLHDKLGPSPL-------RDTVASALMYHRNEILQPS----LQGP 308

  Fly   280 RTRQRSGEFFTGQIYAVGGLASTGESV--STVEIYDPLTKKWK-MGEQMSMMRSRVGVAVLNGKL 341
            :|..|| :|..  :...||:.||..::  ...:..:||..:|| ....::...|..|:||||..:
Mouse   309 QTELRS-DFQC--VVGFGGIHSTPSTILSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFV 370

  Fly   342 YAFGGFN---GTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTV 403
            |..||.|   |....|....||||.|:|.|..::..:.:.:.|..:...||...|.|....|:.|
Mouse   371 YLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLCVCVVGKYIYAVAGRDYHNDLSAV 435

  Fly   404 EVYYPKSNTWKTVAQMMK--YRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPM 466
            |.|.|.:|:|..||.:.|  |..||  |.|.|.:|...|..|.........||...:.|..::..
Mouse   436 ERYDPATNSWDYVAPLKKEVYAHAG--TTLQGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADG 498

  Fly   467 LNRRCRLGVATLNGKIYVCGGYCGNSFLR----SVECYDPQTDTWKLVTPMNCKRSRVALAANMG 527
            ..||...|:|.|..|::|.||...::..|    .|.||...:..|..|.|:........:|....
Mouse   499 PVRRAWHGMAALLDKLFVIGGSNNDAGYRRDVHQVACYSCTSRQWSSVCPLPAGHGEPGIAVLDS 563

  Fly   528 KLWAIGG--YDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            :::.:||  ::..|....|.:||.|.|.|...|.:.....|:.|.|:.:
Mouse   564 RIYVLGGRSHNRGSRTGYVHIYDMEKDCWEEGPQLNNSISGLAACVLTL 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	32/104 (31%)
		PHA03098	36..510	CDD:222983	141/497 (28%)
		KELCH repeat	329..372	CDD:276965	19/45 (42%)
		KELCH repeat	376..417	CDD:276965	12/40 (30%)
		KELCH repeat	423..466	CDD:276965	11/42 (26%)
		KELCH repeat	470..514	CDD:276965	15/47 (32%)
		Kelch_1	517..560	CDD:396078	11/44 (25%)
		KELCH repeat	517..560	CDD:276965	11/44 (25%)
Klhl22	NP_001365953.1	BTB_POZ_KLHL22	46..170	CDD:349560	33/109 (30%)
		PHA03098	71..611	CDD:222983	154/557 (28%)
		BACK_KLHL22	166..269	CDD:350536	25/102 (25%)
		KELCH repeat	313..354	CDD:276965	11/43 (26%)
		KELCH repeat	359..404	CDD:276965	19/44 (43%)
		KELCH repeat	408..452	CDD:276965	14/43 (33%)
		KELCH repeat	455..500	CDD:276965	12/46 (26%)
		KELCH repeat	502..550	CDD:276965	15/47 (32%)
		KELCH repeat	553..599	CDD:276965	11/45 (24%)