Protein Alignment KLHL18 and Klhl11

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_766153.1
• Gene: Klhl11 / 217194
• MGIID: 2388648
• Length: 709
• Species: Mus musculus
• Alignment Length: 571
• Identity: 144/571 - (25%)
• Similarity: 242/571 - (42%)
• Gaps: 50/571 - (8%)

  Fly    31 EIRRMGKLCDVTL---KVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMK----ESAIE 88
            |.||.|..||:||   ....:.|.|||.||||...||..:.:...:|||...:.|:    |...|
Mouse    87 EQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPE 151

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            |..:|::|.|:|:|::|:...:|..::..|....|..:::.|..||..:.|..|.:.|.:.|...
Mouse   152 PDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMY 216

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDK 218
            ...||...|...|.:||.||.|.|||..|....:.:.:...|:.|.:|||:||..:|||:...::
Mouse   217 TLSQLALKAADMIRRNFYKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEE 281

  Fly   219 RSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQ 283
            |...|.::...:||..:.|.:|...|..|.|:.::..|..|:.||.:.|.:  |...:||...:|
Mouse   282 RERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAEAVERHAL--RAENIQSGTLQQ 344

  Fly   284 RSGEFFT----GQ----IYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGK 340
            .:.:...    ||    |..:||::..|:.:|....|.....:|.....:........||:....
Mouse   345 PTSQVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAITESY 409

  Fly   341 LYAFG----GFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVT-SL 400
            :|..|    ||     ..|||.|:|..|.|...|:::.::.:.|:..:...:|..||:...: ..
Mouse   410 VYVAGSMEPGF-----AKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGF 469

  Fly   401 NTVEVYYPKSNTWKTVAQMMK-YRSAGGVTQLNGYVYALG-------GHDGLSIFDSVERYDQAE 457
            ..|.||.|:.:.|..:....| .|....:...:.:||...       ..|||...  :..||...
Mouse   470 KDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAV--ITCYDTET 532

  Fly   458 DVW--VKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSF-LRSVECY-----DPQTDTWKLVTPMN 514
            ..|  |:..|:::..|...::.:|...|.....|..|: |.:.|..     ....:..:.:.|..
Mouse   533 RQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYSLENEEAVRKIAGQVSDEILESLPPEV 597

  Fly   515 CKRSRVALAANMGKLWAIGGYDGESNL-----STVEVYDPETDKWTFMPPM 560
            ......|:......::.|||:....::     .....|..|..:|..:|||
Mouse   598 LSIEGAAICYYRDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPM 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	37/112 (33%)
		PHA03098	36..510	CDD:222983	130/509 (26%)
		KELCH repeat	329..372	CDD:276965	14/46 (30%)
		KELCH repeat	376..417	CDD:276965	9/41 (22%)
		KELCH repeat	423..466	CDD:276965	10/51 (20%)
		KELCH repeat	470..514	CDD:276965	8/49 (16%)
		Kelch_1	517..560	CDD:396078	8/47 (17%)
		KELCH repeat	517..560	CDD:276965	8/47 (17%)
Klhl11	NP_766153.1	BTB_POZ_KLHL11	72..206	CDD:349550	38/118 (32%)
		PHA03098	91..554	CDD:222983	124/471 (26%)
		BACK_KLHL11	201..288	CDD:350526	29/86 (34%)
		Kelch 1	361..408		9/46 (20%)
		KELCH repeat	400..440	CDD:276965	14/44 (32%)
		Kelch 2	409..454		13/49 (27%)
		KELCH repeat	444..489	CDD:276965	9/44 (20%)
		Kelch 3	456..502		10/45 (22%)
		KELCH repeat	492..542	CDD:276965	10/51 (20%)
		Kelch 4	504..557		11/54 (20%)
		KELCH repeat	568..650	CDD:276965	14/81 (17%)
		Kelch 5	611..662		9/38 (24%)
		Kelch	612..658	CDD:128874	9/37 (24%)