DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KLHL18 and Klhl29

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_001157965.1 Gene:Klhl29 / 208439 MGIID:2683857 Length:875 Species:Mus musculus


Alignment Length:565 Identity:171/565 - (30%)
Similarity:268/565 - (47%) Gaps:88/565 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 GESFPLFKEI---RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNM---AESRIKEIT 81
            |....:.||:   ||.....|:.:.||.:.|..|:.|||:...||..:...::   ::|..:::.
Mouse   310 GHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREKLE 374

  Fly    82 MKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGI 146
            :..|.::...||.|:.:||:|.:.||:.|.:.|:..||..|.......|.|||..:....|.||:
Mouse   375 LVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439

  Fly   147 RTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKW 211
            ...|::|.|.:|...|..:..|.|.:|:..||.|::..:..:..:..|.||.:.||:::|..:||
Mouse   440 LAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKW 504

  Fly   212 VKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLL 276
            :|.....|::...::|||||||.:.|.:|.:.|..||||:||..||||::|||.:|::|..|..:
Mouse   505 IKKDPATRAQYAAELLAAVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEM 569

  Fly   277 QSFRTR-----------------------QRS------------------------GEFFT---- 290
            |:.|||                       |||                        .|||:    
Mouse   570 QTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSA 634

  Fly   291 -GQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLS 354
             ..||..||:.| |.:::.|..|..|...|.:..:|::.|.|....|.:||:|..||......:.
Mouse   635 GDNIYLSGGMES-GVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVD 698

  Fly   355 TVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDC---IYVCGGY-DGVTSLNTVEVYYPKSNTWKT 415
            .||.||...|:| :..|.|.|  ||..||...|   |||.||. :...:...::.|.|::|||..
Mouse   699 HVERYDTITNQW-EAVAPLPK--AVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSF 760

  Fly   416 V-AQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVW------VKMSPMLNR-RCR 472
            : :.|:..:.|..|| |||:|:.|||           .|.:|..::      :|..|.:|. |..
Mouse   761 IESPMIDNKYAPAVT-LNGFVFILGG-----------AYARATTIYDPEKGNIKAGPNMNHSRQF 813

  Fly   473 LGVATLNGKIYVCGGYCGNS--FLRSVECYDPQTDTWKLVTPMNC 515
            .....|:||||..||...:.  .|.::|.|:|.|:||.|:..|.|
Mouse   814 CSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPC 858

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 34/119 (29%)
PHA03098 36..510 CDD:222983 163/542 (30%)
KELCH repeat 329..372 CDD:276965 14/42 (33%)
KELCH repeat 376..417 CDD:276965 15/45 (33%)
KELCH repeat 423..466 CDD:276965 13/48 (27%)
KELCH repeat 470..514 CDD:276965 16/45 (36%)
Kelch_1 517..560 CDD:396078
KELCH repeat 517..560 CDD:276965
Klhl29NP_001157965.1 PHA03247 <39..290 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..145
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..291
BTB_POZ 312..438 CDD:453885 34/125 (27%)
PHA03098 333..860 CDD:222983 165/542 (30%)
BACK_KLHL29_KBTBD9 432..533 CDD:350543 32/100 (32%)
KELCH repeat 577..621 CDD:276965 3/43 (7%)
Kelch 1 585..635 6/49 (12%)
KELCH repeat 626..669 CDD:276965 13/43 (30%)
Kelch 2 637..683 14/46 (30%)
KELCH repeat 673..716 CDD:276965 15/43 (35%)
Kelch 3 684..730 18/48 (38%)
KELCH repeat 720..808 CDD:276965 29/99 (29%)
Kelch 4 732..778 15/46 (33%)
Kelch 5 779..821 11/52 (21%)
KELCH repeat 811..857 CDD:276965 16/45 (36%)
Kelch 6 822..870 15/37 (41%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.