Protein Alignment KLHL18 and Klhl25

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_083928.1
• Gene: Klhl25 / 207952
• MGIID: 2668031
• Length: 589
• Species: Mus musculus
• Alignment Length: 559
• Identity: 171/559 - (30%)
• Similarity: 263/559 - (47%)
• Gaps: 68/559 - (12%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:.....||||...|:.|..||.||||:..||.|||::.:.|||...:..::: :.|..||.|:
Mouse    39 LRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDN-LHPEVLELLL 102

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            ::.||.::.|:.:|.::|:.....||..:||||.|.||.....|.|.||:...:|:..||:|.:.
Mouse   103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEF 167

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            :.:....:|..|.|||:|.:|..:.||:|:.||||....|.|:|||.::|||:..::|....|.:
Mouse   168 SCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAHLPLL 232

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEA---KDFHLMPERRGLLQS-FRTRQRSGE 287
            |..|||.||....|.:.|:.|.|:.:....:.:||||   |...|:.:  |::.| |...:::|.
Mouse   233 LRNVRLALLPSDCLKNAVSGEALLMADECTKLILDEAFRCKTKILLND--GVVTSPFARPRKAGH 295

  Fly   288 ---------FFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYA 343
                     |...:||.|...|.  |.:...::..|              |.....:.:..|:|.
Mouse   296 TLLILGGQTFMCDKIYQVDHKAK--EIIPKADLPSP--------------RKEFSASAIGCKVYV 344

  Fly   344 FGGFNGTER--LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGV--------- 397
            .|| .|:|.  ...|.|||....:||:...||..|...|.|.|::|:||.||:..:
Mouse   345 TGG-RGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGIFPASPS 408

  Fly   398 TSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGG----HDGLSIFDSVERYDQAED 458
            .||..||.|.|..|.|..||.|....|...|......::..||    .|.:|   .|:.:|.:|:
Mouse   409 VSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDMVS---KVQCFDPSEN 470

  Fly   459 VWVKMSPMLNRRC-----RLGVATLNGKIYVCGG---YCGNSFLRSVECYDPQTDTWKLVTPMNC 515
            .|.     :...|     ....|.|..:|::.||   |...|..|    :|.:|:.|..:..|..
Mouse   471 RWT-----IKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASAYR----FDCETNQWTRIGDMTA 526

  Fly   516 KRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            ||......|:..||:.:|||.|.....|::.|||.:|.|
Mouse   527 KRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	39/104 (38%)
		PHA03098	36..510	CDD:222983	154/509 (30%)
		KELCH repeat	329..372	CDD:276965	13/44 (30%)
		KELCH repeat	376..417	CDD:276965	17/49 (35%)
		KELCH repeat	423..466	CDD:276965	10/46 (22%)
		KELCH repeat	470..514	CDD:276965	12/51 (24%)
		Kelch_1	517..560	CDD:396078	14/38 (37%)
		KELCH repeat	517..560	CDD:276965	14/38 (37%)
Klhl25	NP_083928.1	BTB_POZ_KLHL25	24..151	CDD:349563	41/112 (37%)
		PHA03098	39..566	CDD:222983	171/559 (31%)
		Kelch 1	296..340		8/59 (14%)
		KELCH repeat	330..374	CDD:276965	13/44 (30%)
		Kelch 2	341..388		18/47 (38%)
		KELCH repeat	378..431	CDD:276965	19/52 (37%)
		Kelch 3	389..444		18/54 (33%)
		KELCH repeat	434..480	CDD:276965	11/53 (21%)
		Kelch 4	446..492		11/53 (21%)
		KELCH repeat	482..524	CDD:276965	11/45 (24%)
		Kelch 5	493..538		13/48 (27%)
		KELCH repeat	528..565	CDD:276965	13/36 (36%)
		Kelch 6	539..585		12/27 (44%)