DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and bath-36

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_506750.1	Gene:	bath-36 / 190718	WormBaseID:	WBGene00013569	Length:	320	Species:	Caenorhabditis elegans

Alignment Length:	207	Identity:	48/207 - (23%)
Similarity:	93/207 - (44%)	Gaps:	29/207 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DNSQVEDQYFVYK-----------HDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLA 58
            ||..|.|::.|.:           |:::. |:|...||     .|.||.|.:|.:.....:.|||
Worm   121 DNRFVLDKHAVLEVQITVNKIAGIHERII-ETFDQPKE-----HLTDVVLVLEGKHVHVGKQVLA 179

  Fly    59 ATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQL 123
            .:..:|..||.:|.||....||.:.:  :..|....|:|.:|...:.|::.||.:|:..:....:
Worm   180 TSSQFFQKMFYSNFAEKTQAEIKIDD--VTHSEFIDLLNVIYPTHMLINSSNVSHLLKLSDRFAV 242

  Fly   124 SNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYID--QNFAKVSQSEEFLALD--- 183
            ..|.:...:|||.....|.:..:: ||:.....:|.:|....::  ::...:...|.:.:||
Worm   243 PRVLEKAETFLILDQKTHLIDKLK-FAEVYRLSRLQNACLSQLETSEDVTALKHHENYKSLDHIT 306

  Fly   184 ----CEQLLELM 191
                .::|::|:
Worm   307 YNALLQKLIDLL 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	28/105 (27%)
		PHA03098	36..510	CDD:222983	38/165 (23%)
		BACK	143..245	CDD:285009	9/58 (16%)
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965
		Kelch	340..386	CDD:128874
		KELCH repeat	376..417	CDD:276965
		Kelch	387..433	CDD:128874
		KELCH repeat	423..466	CDD:276965
		Kelch	435..480	CDD:128874
		Kelch_1	469..514	CDD:279660
		KELCH repeat	470..514	CDD:276965
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
bath-36	NP_506750.1	MATH	8..137	CDD:295307	5/15 (33%)
		BTB	156..254	CDD:279045	28/104 (27%)
		BTB	161..254	CDD:197585	25/94 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910