DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and bath-25

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001317756.1	Gene:	bath-25 / 188993	WormBaseID:	WBGene00020859	Length:	298	Species:	Caenorhabditis elegans

Alignment Length:	158	Identity:	38/158 - (24%)
Similarity:	61/158 - (38%)	Gaps:	42/158 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMG---------KLCDVTLKVEDQTFSAHRVVL 57
            |..:...:|:|:.:  .|.:..|.....|.|.|..         :..||.|..|.|.|...::.|
Worm   101 DFMNWEDMENQFLI--DDSIRMECHVELKYIERTSYRKFDESAKEFSDVILVAEKQKFYVSKLFL 163

  Fly    58 AATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVY--------SGQVRIDNQNVQNL 114
            :....||:|:...|..||...||.:|:           :|..|        .|:..|..:||:::
Worm   164 SFQSSYFHALLLGNFIESTSSEIELKD-----------VNSTYFQYFLELLHGESSITAENVEHI 217

  Fly   115 MVGASFLQLSNVRDA------CASFLIS 136
                  |.|:::.||      |..||.|
Worm   218 ------LHLADMFDARTAIRRCEEFLNS 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	31/128 (24%)
		PHA03098	36..510	CDD:222983	30/124 (24%)
		BACK	143..245	CDD:285009
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965
		Kelch	340..386	CDD:128874
		KELCH repeat	376..417	CDD:276965
		Kelch	387..433	CDD:128874
		KELCH repeat	423..466	CDD:276965
		Kelch	435..480	CDD:128874
		Kelch_1	469..514	CDD:279660
		KELCH repeat	470..514	CDD:276965
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
bath-25	NP_001317756.1	MATH	14..126	CDD:334312	5/26 (19%)
bath-25	NP_001317756.1	BTB	146..237	CDD:197585	27/107 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910