DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and bath-4

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_494122.1	Gene:	bath-4 / 186090	WormBaseID:	WBGene00018665	Length:	306	Species:	Caenorhabditis elegans

Alignment Length:	173	Identity:	43/173 - (24%)
Similarity:	76/173 - (43%)	Gaps:	32/173 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFKEIRRMGK----LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE 88
            |.|:::...|    ..||.|.|||:||...:..||:...||.|:......|:.|.|:.:|:  |:
Worm   135 LKKKLKSFEKSEEQFSDVILAVEDETFHVLKKFLASHSTYFNALLLGKFKEAEISEVALKD--ID 197

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            .:..::|:..:| |:..||...::.::..|....:......|..|||.            |::..
Worm   198 STDFQNLLEVLY-GESAIDEDTIEGILHLAHMYDMPFPTRKCEEFLID------------FSEKP 249

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDEL 196
            | ::.:..|.||         |.|: |.:.|  |::....||:
Worm   250 I-KEKLKVAKKY---------QLED-LKMSC--LMKTNTIDEI 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	28/109 (26%)
		PHA03098	36..510	CDD:222983	41/165 (25%)
		BACK	143..245	CDD:285009	12/54 (22%)
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965
		Kelch	340..386	CDD:128874
		KELCH repeat	376..417	CDD:276965
		Kelch	387..433	CDD:128874
		KELCH repeat	423..466	CDD:276965
		Kelch	435..480	CDD:128874
		Kelch_1	469..514	CDD:279660
		KELCH repeat	470..514	CDD:276965
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
bath-4	NP_494122.1	MATH	14..128	CDD:279285
		BTB	145..243	CDD:279045	26/100 (26%)
		BTB	151..246	CDD:197585	28/109 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910