Protein Alignment KLHL18 and C53A5.9

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_506605.2
• Gene: C53A5.9 / 183739
• WormBaseID: WBGene00008267
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 560
• Identity: 126/560 - (22%)
• Similarity: 204/560 - (36%)
• Gaps: 170/560 - (30%)

  Fly    18 HDKLFGESFPLFKEIRRMGK-------LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAES 75
            |.|...:|.....|::....       :||..|:.:|                  |.|:.:..|:
 Worm    12 HTKNASQSVTALDELKTPSSEVADAWDVCDQPLEYQD------------------AQFSESEMET 58

  Fly    76 RIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHP 140
            ::||  :::.:||.|              |:..:|:|........|||:           ...:|
 Worm    59 QMKE--LEDCSIEAS--------------RVFLENLQKSFKLMKLLQLT-----------QSLNP 96

  Fly   141 HNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIF 205
            .         :|...|::|....|.|:..   |||
 Worm    97 Q---------ESSYNRKIISTEMKKINDT---VSQ------------------------------ 119

  Fly   206 EACMKWVKYAEDKRSELFPQVLAAVRL----------PLLSPQFLADRVAREELIRSSHQCRDLL 260
                  :||| .||.|:..:.|...|.          |.:.|..:||:.      :|:|  :.||
 Worm   120 ------LKYA-GKRIEMINEHLEKHRFTGKDGDAFLEPNMDPVLIADQA------QSAH--KPLL 169

  Fly   261 DEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQM 325
                                               :|.             :||.|:|:|...::
 Worm   170 -----------------------------------IGS-------------FDPKTQKYKPIGRL 186

  Fly   326 SMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYV 390
            ...|:...||.....||..||.:..:.|:..|.|:.:||....|..:..||:.......:..:||
 Worm   187 PDPRANFAVASSKTNLYVIGGTHNGQFLNKFEYYNQKKNARCMGANLNHKRTKPAAGFHNGALYV 251

  Fly   391 CGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQ 455
            .||||.: .|::||:|..:..|||....:...|:...|....|.::.|||.:|.|..:|:|:...
 Worm   252 VGGYDSI-YLSSVELYDLEEGTWKNGPSLNNCRANAAVVACYGEIFVLGGFNGKSNEESIEKISA 315

  Fly   456 AEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCG-NSFLRSVECYDPQTDTWKLVTPMNCKRSR 519
            :.:.:.....|...|...|.....|:||:.||:.. .:.|:||..|||.|.||:....|...|..
 Worm   316 SGNEFEIFGEMEGGRSGFGACVFQGRIYIAGGWSNTRNTLKSVRSYDPYTKTWRDEPSMKNARKA 380

  Fly   520 VALAANMGKLWAIGGYDGESN-LSTVEVYDPETDKWTFMP 558
            ..|.|....::||.|||.||. |..:|.:||:..||:.:|
 Worm   381 FTLHATNEAIYAIRGYDEESALLDQIERFDPKKLKWSIVP 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	21/123 (17%)
		PHA03098	36..510	CDD:222983	104/491 (21%)
		KELCH repeat	329..372	CDD:276965	13/42 (31%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		KELCH repeat	423..466	CDD:276965	10/42 (24%)
		KELCH repeat	470..514	CDD:276965	16/44 (36%)
		Kelch_1	517..560	CDD:396078	17/43 (40%)
		KELCH repeat	517..560	CDD:276965	17/43 (40%)
C53A5.9	NP_506605.2	NanM	181..424	CDD:442289	74/241 (31%)
		KELCH repeat	190..234	CDD:276965	13/43 (30%)
		KELCH repeat	237..279	CDD:276965	14/42 (33%)
		KELCH repeat	283..327	CDD:276965	10/43 (23%)
		KELCH repeat	330..375	CDD:276965	16/44 (36%)
		KELCH repeat	378..421	CDD:276965	17/43 (40%)