Protein Alignment KLHL18 and rike-1

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001407540.1
• Gene: rike-1 / 183737
• WormBaseID: WBGene00008266
• Length: 576
• Species: Caenorhabditis elegans
• Alignment Length: 442
• Identity: 111/442 - (25%)
• Similarity: 192/442 - (43%)
• Gaps: 53/442 - (11%)

  Fly   145 GIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACM 209
            |.:|...:::...:.|.|...:....:|:|:..:.:   |:.:.:   :....:::.:..||
 Worm   162 GHQTMQLALLKNSIEDQAPTNLGNKISKISELSKQV---CDDISD---KFAATIKSLQNYFE--- 217

  Fly   210 KWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRG 274
            |..|.:...|...|..:.|.:       :.::|.:|   |::.:....|.|:...:.|    .|.
 Worm   218 KHEKLSPPGRKTHFNNIEAEM-------EKISDTIA---LVKDAGTRLDFLNNEIEEH----DRI 268

  Fly   275 LLQSFRTRQRSGEFFTGQ--IYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVL 337
            :.|:.:...::...|..|  :.......|..|.: .:.:|||..:.|....:|...:|...||..
 Worm   269 VFQTKQPVTKANFVFASQDPVLVADRKQSAREPL-LIGVYDPKNRGWTPVGRMPNPKSNYAVACS 332

  Fly   338 NGKLYAFGGFNGTERLSTVEVYDPRK---------NKWSQGCAMLCKRSAVGVAALDDCIYVCGG 393
            ..::|..||.|....|:.||:||..|         ||..:|..    |::.|:.  ::.:||.||
 Worm   333 KSQIYIVGGMNNGSWLNNVEMYDREKNLRRDLLQCNKMKRGRT----RTSAGIH--NNKMYVAGG 391

  Fly   394 YDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAED 458
            ||. |.:|:||||......||....:.:.|:...|...||.||.|||.:|....:.:|:..:...
 Worm   392 YDS-TYMNSVEVYDTDQGEWKDGPSLQRPRADAAVVPCNGEVYVLGGFNGKEYEEKIEKLSEPGQ 455

  Fly   459 VWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNS-FLRSVECYDPQTDTWKLVTPMNCKRSRVAL 522
            .:..:..|...|...|.....|:||:.||:..:| .||||..|||.|.:|:....::..|....|
 Worm   456 KFEIVGDMQGSRAGFGSCAFRGRIYIAGGWSNSSNTLRSVRSYDPLTKSWRDEPSLSKDRKYFTL 520

  Fly   523 AANMGKLWAIGG-YDGESNLSTVEVYDPETDKWTFMP---PMCAHSGGVGAG 570
            .:....::||.| .|..|.::.||.:|||...|..:.   ||      ||||
 Worm   521 HSTNEAIYAIRGCADNWSLINEVERFDPEKRAWEIISCSGPM------VGAG 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556
		PHA03098	36..510	CDD:222983	92/376 (24%)
		KELCH repeat	329..372	CDD:276965	16/51 (31%)
		KELCH repeat	376..417	CDD:276965	16/40 (40%)
		KELCH repeat	423..466	CDD:276965	11/42 (26%)
		KELCH repeat	470..514	CDD:276965	17/44 (39%)
		Kelch_1	517..560	CDD:396078	13/46 (28%)
		KELCH repeat	517..560	CDD:276965	13/46 (28%)
rike-1	NP_001407540.1	RING-HC_RNF222	7..56	CDD:438226
		NanM	306..547	CDD:442289	75/247 (30%)
		KELCH repeat	325..370	CDD:276965	14/44 (32%)
		KELCH repeat	374..416	CDD:276965	16/48 (33%)
		KELCH repeat	420..464	CDD:276965	11/43 (26%)
		KELCH repeat	467..511	CDD:276965	17/43 (40%)
		KELCH repeat	515..557	CDD:276965	13/41 (32%)