DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and bath-24

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_494163.1	Gene:	bath-24 / 181826	WormBaseID:	WBGene00015014	Length:	242	Species:	Caenorhabditis elegans

Alignment Length:	199	Identity:	44/199 - (22%)
Similarity:	82/199 - (41%)	Gaps:	38/199 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKE 84
            |.|.||...|.         ||.:.|.::.|...:|.||:...||..:|.....|:...|:|:::
Worm    65 KSFDESNEEFS---------DVVVAVGNEKFYVLKVYLASHSTYFKTLFLGKFVEADKSEVTLQD 120

  Fly    85 SAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTF 149
              |:|:..:.|:..:: |:..||:..:..::..|....:|........||:.:
Worm   121 --IDPTDFQCLMEVIH-GESAIDDSTIDGVLQLAQMFDVSLAIRKSEEFLVEK------------ 170

  Fly   150 ADSMICRQLIDAADKYIDQN-----FAKVSQSEEFLA--------LDCEQLLELMRRDELNVRTE 201
             .....|.|:..|.::..:|     .:|::..:|..|        :|...|.||:::....||..
Worm   171 -SKKSMRDLLKLAKQFQLENLKTVCLSKINTLDEIEASMAHNPAEMDPSVLAELLKKSTALVRMN 234

  Fly   202 EVIF 205
            ||:|
Worm   235 EVLF 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	23/105 (22%)
		PHA03098	36..510	CDD:222983	39/183 (21%)
		BACK	143..245	CDD:285009	16/76 (21%)
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965
		Kelch	340..386	CDD:128874
		KELCH repeat	376..417	CDD:276965
		Kelch	387..433	CDD:128874
		KELCH repeat	423..466	CDD:276965
		Kelch	435..480	CDD:128874
		Kelch_1	469..514	CDD:279660
		KELCH repeat	470..514	CDD:276965
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
bath-24	NP_494163.1	MATH	<5..53	CDD:295307
		BTB	70..168	CDD:279045	24/109 (22%)
		BTB	76..171	CDD:197585	23/110 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910