Protein Alignment KLHL18 and ivns-1

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_510109.1
• Gene: ivns-1 / 181410
• WormBaseID: WBGene00006493
• Length: 817
• Species: Caenorhabditis elegans
• Alignment Length: 674
• Identity: 156/674 - (23%)
• Similarity: 253/674 - (37%)
• Gaps: 166/674 - (24%)

  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIK------------------- 78
            ||..:|||..|.|:::....|:|||||..|....||......|:.:
 Worm    88 RRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKSPTSSSPTNGHTNGITNG 152

  Fly    79 --EITMKE----SAIEP---------------SALESLINYVYSGQVRIDNQNVQNLMVGASFLQ 122
              |:..:.    ||.:|               ...|:|:|:.|:..:.|.::.|..|...|..||
 Worm   153 NGEVAHENGAPVSAQKPQKSSTTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQ 217

  Fly   123 LSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNF-AKVSQSEEFLALDCEQ 186
            :..|..|||::|.......|.:|||..|:......|:...|::|..|| :.|:.|:||..|...|
 Worm   218 MIPVIRACAAYLAENLQLSNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNDSKEFTQLPVIQ 282

  Fly   187 LLELMRRDE----LNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAA-VRLPLLSPQFLADRVAR 246
            :..::..::    .|......:.|..:.:.:.....|:|....:|.. ..:..:....|||.:..
 Worm   283 VRIIVPAEDGKVTNNANNNGGLAEMALFYFQNMPHDRAEHSIDLLTCKTHILYMEENHLADCIEM 347

  Fly   247 EELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQ--------IYAVGG----- 298
            :|  |||....|::.:.|            :|.:.|:...:..|.|        .:.|.|
 Worm   348 DE--RSSVGSCDIIQDYK------------KSGKDRKDVAKAMTAQEPIINSVVQHRVNGAVPVR 398

  Fly   299 ---------------------------------LASTGES-----VSTVEIYDPLT--------- 316
                                             |.||.::     |:.|.:|..|.
 Worm   399 LNASRLPNMNASNESLESAGTDDSDPQDTIEARLISTHQTAPQYWVALVVLYRRLCVLSLQLTDN 463

  Fly   317 -----------------------------KKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTER 352
                                         |:.|..|.||..|..:|.:.||||::..||::..|.
 Worm   464 EELLRTKREPCPVDSQKAALLSRLISCTGKQQKPLECMSAPRCSIGASFLNGKIFVCGGYDRGEC 528

  Fly   353 LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDC------IYVCGGYDGVTSLNTVEVYYPKSN 411
            |.:||.||....||.....|..:|...      ||      ::...|.:|...|.:.|:|.||::
 Worm   529 LRSVEEYDVVNGKWRNVAKMKAERGRF------DCTIHGGKVFAVAGSNGNNDLKSCEIYDPKAD 587

  Fly   412 TWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQA-----EDVWVKMSPMLNRRC 471
            .|..:..:...|...|...::.|||.:||.....:....||.|..     |..|..|:.|.:.|.
 Worm   588 VWAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLDTTKLGTEEAEWEPMASMEHPRY 652

  Fly   472 RLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYD 536
            :.||.|..|.:...||....:.:.|||.:||:|:.|:.:..:...|...|:|.....|:.|||:|
 Worm   653 QAGVCTWKGLVVAAGGCDRWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHD 717

  Fly   537 GESNLSTVEVYDPETDKWTFMPPM 560
            |..:|.|||:.|..:.:|...|.:
 Worm   718 GTQSLDTVEILDSPSSQWRVGPTL 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	36/143 (25%)
		PHA03098	36..510	CDD:222983	138/619 (22%)
		KELCH repeat	329..372	CDD:276965	16/42 (38%)
		KELCH repeat	376..417	CDD:276965	11/46 (24%)
		KELCH repeat	423..466	CDD:276965	13/47 (28%)
		KELCH repeat	470..514	CDD:276965	14/43 (33%)
		Kelch_1	517..560	CDD:396078	16/42 (38%)
		KELCH repeat	517..560	CDD:276965	16/42 (38%)
ivns-1	NP_510109.1	BTB_POZ	77..241	CDD:453885	37/152 (24%)
		PHA03098	183..735	CDD:222983	133/571 (23%)
		NanM	501..763	CDD:442289	74/247 (30%)
		KELCH repeat	505..548	CDD:276965	16/42 (38%)
		KELCH repeat	552..596	CDD:276965	11/49 (22%)
		KELCH repeat	599..647	CDD:276965	13/47 (28%)
		KELCH repeat	651..695	CDD:276965	14/43 (33%)
		KELCH repeat	698..743	CDD:276965	16/44 (36%)