Protein Alignment KLHL18 and kel-3

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_499784.2
• Gene: kel-3 / 176775
• WormBaseID: WBGene00002185
• Length: 591
• Species: Caenorhabditis elegans
• Alignment Length: 556
• Identity: 250/556 - (44%)
• Similarity: 361/556 - (64%)
• Gaps: 4/556 - (0%)

  Fly    19 DKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMK 83
            |:::.:|:.:|.|:|...:||||.|.||::..|||:|:||||||||..|||.::.|:.:|||.::
 Worm    31 DEMYKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIE 95

  Fly    84 ESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRT 148
            :|.:....:::|:::.|:|::||...|||::|:||:|.|:..|...|.:||::|.||.|.|.||.
 Worm    96 DSDMNYETVDALLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSIRE 160

  Fly   149 FADSMIC--RQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKW 211
            |. .|:|  .::.:..|.||.::|..||:.|:|..|..|..:||:|.|.|.|.:||.::.|.|:|
 Worm   161 FC-KMMCVEEKITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEW 224

  Fly   212 VKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLL 276
            :. .:..|.|...::|..||||||||.:|:..||...:|:....||||:|||||:||:|:||.|:
 Worm   225 LN-CDVIRHEQAAKILPCVRLPLLSPTYLSSIVASNPIIKKDIPCRDLIDEAKDYHLLPDRRSLI 288

  Fly   277 QSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKL 341
            :||:...|..:...|.|.|:|||....:|.|:||||||.:|||...:.|..:|:||||||...::
 Worm   289 KSFKCTPRLCQIVPGLIVAIGGLMHQSQSKSSVEIYDPTSKKWSPIDGMVTLRTRVGVAVNQRQV 353

  Fly   342 YAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVY 406
            ||.|||||.:||..||.:|....||:....:..||||:..|.:.:.:||||||||:.||:::|:|
 Worm   354 YAIGGFNGQDRLDLVEKFDYDTLKWTTLSPLTRKRSALAAAFVTNRLYVCGGYDGLHSLSSIEIY 418

  Fly   407 YPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRC 471
            ....|.|:....|...|||.|||.::.::|..|||||:.||.||||.|.....|.::..|:.:||
 Worm   419 DINRNVWEAGPPMENMRSAAGVTVIDKHIYICGGHDGMQIFASVERLDTENQQWERIPSMIQQRC 483

  Fly   472 RLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYD 536
            |.|.||..|||||.|||.|.|||:|||.|||....|..|:|||.:||||:|.:....|:|:.|:|
 Worm   484 RFGAATFKGKIYVAGGYDGTSFLKSVEVYDPVEKKWSPVSPMNMRRSRVSLVSTNEGLFAVAGFD 548

  Fly   537 GESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVI 572
            ||:||.::|.||..||.||....:..|.||||.|||
 Worm   549 GENNLCSMEQYDDVTDSWTIATALTCHEGGVGVGVI 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	48/116 (41%)
		PHA03098	36..510	CDD:222983	213/475 (45%)
		KELCH repeat	329..372	CDD:276965	21/42 (50%)
		KELCH repeat	376..417	CDD:276965	18/40 (45%)
		KELCH repeat	423..466	CDD:276965	20/42 (48%)
		KELCH repeat	470..514	CDD:276965	27/43 (63%)
		Kelch_1	517..560	CDD:396078	20/42 (48%)
		KELCH repeat	517..560	CDD:276965	20/42 (48%)
kel-3	NP_499784.2	BTB_POZ	32..149	CDD:453885	48/116 (41%)
		PHA03098	51..568	CDD:222983	235/518 (45%)
		KELCH repeat	341..384	CDD:276965	21/42 (50%)
		KELCH repeat	388..431	CDD:276965	18/42 (43%)
		KELCH repeat	435..479	CDD:276965	20/43 (47%)
		KELCH repeat	482..527	CDD:276965	28/44 (64%)
		KELCH repeat	529..572	CDD:276965	20/42 (48%)