Protein Alignment KLHL18 and F47D12.7

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_498380.1
• Gene: F47D12.7 / 175891
• WormBaseID: WBGene00018563
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 587
• Identity: 146/587 - (24%)
• Similarity: 244/587 - (41%)
• Gaps: 97/587 - (16%)

  Fly     6 NSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKV---EDQTFSAHRVVLAATIPYFYAM 67
            ||.:|:.  ..|..|...|....|:|....    .|||.:   |:..|.  |.:|:....||..:
 Worm    24 NSSIEES--PVKRVKFSPELTKSFEETLSP----TVTLVLRNNEEVIFD--RYLLSFYSNYFRVL 80

  Fly    68 FTNNMAES-----RIKEITMKE---SAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLS 124
            |::...:|     ||:.|:..:   ....|.|.|..|      :..|..|....|:..|:|||:|
 Worm    81 FSSKFRDSNSTTHRIRLISASDLHFLLTIPKAFEQGI------KPNITLQKAIELLEPAAFLQMS 139

  Fly   125 NVRDACASFLISRFHPHNVLGI-------RTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLAL 182
            ...|..:..:.......|::.|       .|.....:.|.::        :.|..:..:..:|:|
 Worm   140 IALDYISDIICKNLTHENIIKIFRLALLYHTTLAVRVWRSMV--------RKFQTLFATNVYLSL 196

  Fly   183 DCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVARE 247
            ...:|:.|:....||:::|:.. ...:.|:|:....:|:         ||    .||.....:|
 Worm   197 KENELIGLLTDKHLNLKSEDET-TVVVNWIKHNSPLQSD---------RL----TQFAQRNFSR- 246

  Fly   248 ELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIY 312
                     |...|..|           .:..||||.     ...|...||.||.|.: ..:|:.
 Worm   247 ---------RPQPDATK-----------YEVIRTRQP-----MDAIVCFGGWASRGVA-QKIEVC 285

  Fly   313 DPLTKKWKM----GEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAML 373
            :..:.:|:.    .:..::.|:..|:.|:..||..:|||:|.::..|..::|....:|.:|..|.
 Worm   286 NTRSDRWQTCNFNYDIPNIHRAYHGIEVVEDKLIVYGGFDGIKQFQTTVLFDLSTKEWRRGANMN 350

  Fly   374 CKRSAVGVAALDD-----CIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNG 433
            .||..|..|.::|     .::.|||.:||:.|.|.|:|..:::.|..||.|.:.||.|.|..::.
 Worm   351 DKRCYVTSARVNDSYGRPLVFACGGMNGVSRLKTAEMYDYRADQWTEVANMTQMRSDGAVVTIDN 415

  Fly   434 YVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLG---VATLNGKIYVCGGYCGNSFLR 495
            .:.|:||.||.:|....|.||...|:|..:|..:..| |.|   |:.:|....:.||:.||..|.
 Worm   416 KIVAIGGFDGRNIHQGGEVYDPVLDLWHPLSSNMRTR-RTGCTAVSIMNQVCMIIGGFNGNRRLD 479

  Fly   496 SVECYDPQTDTWKLVTPMNCKRSRVALAANMGK--LWAIGGYDGESNLSTVEVYDPETDKWTFMP 558
            |.|.||.:...|.....:...||..: |..|..  ::..||:||::.....|..|..:..|..:|
 Worm   480 SAEIYDMREGLWHPEPTLQTARSNFS-ACQMDTCYVYVAGGFDGQTTTKESERLDLRSKMWQALP 543

  Fly   559 PM 560
            .|
 Worm   544 DM 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	31/127 (24%)
		PHA03098	36..510	CDD:222983	125/503 (25%)
		KELCH repeat	329..372	CDD:276965	13/42 (31%)
		KELCH repeat	376..417	CDD:276965	14/45 (31%)
		KELCH repeat	423..466	CDD:276965	16/42 (38%)
		KELCH repeat	470..514	CDD:276965	15/46 (33%)
		Kelch_1	517..560	CDD:396078	12/44 (27%)
		KELCH repeat	517..560	CDD:276965	12/44 (27%)
F47D12.7	NP_498380.1	PHA03098	44..554	CDD:222983	140/565 (25%)
		NanM	306..559	CDD:442289	76/242 (31%)
		KELCH repeat	306..349	CDD:276965	13/42 (31%)
		KELCH repeat	353..402	CDD:276965	16/48 (33%)
		KELCH repeat	405..447	CDD:276965	15/41 (37%)
		KELCH repeat	453..499	CDD:276965	14/45 (31%)
		KELCH repeat	501..545	CDD:276965	12/44 (27%)