DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and bath-38

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_496172.1	Gene:	bath-38 / 174567	WormBaseID:	WBGene00009945	Length:	387	Species:	Caenorhabditis elegans

Alignment Length:	179	Identity:	42/179 - (23%)
Similarity:	78/179 - (43%)	Gaps:	23/179 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSG 102
            :||:||.:..|....::..||...|.|||||.:|..|....::.:::..:|  ....|::.:|..
Worm   227 ICDMTLVINKQKLFVNKAYLALYSPVFYAMFFSNFQEREKTQVELEDVVLE--EFRELLHVIYPC 289

  Fly   103 QVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIR--TFADSMICRQLIDAADKY 165
            ...|.:.||:.|:......::..|.|.|..||:.   ..::|.|.  .:||..:..:|.|:..:.
Worm   290 HKPITSDNVEYLLELGDKYEIQYVMDECERFLVG---SEDILQITKLMWADQYLLAKLQDSCLRN 351

  Fly   166 IDQ--NFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWV 212
            |.:  :...:..:|||              ..|:..|:..:.|..:|.|
Worm   352 IKEVSDVKAIKLTEEF--------------KNLSDATKAALLEKVLKIV 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	26/96 (27%)
		PHA03098	36..510	CDD:222983	42/179 (23%)
		BACK	143..245	CDD:285009	15/74 (20%)
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965
		Kelch	340..386	CDD:128874
		KELCH repeat	376..417	CDD:276965
		Kelch	387..433	CDD:128874
		KELCH repeat	423..466	CDD:276965
		Kelch	435..480	CDD:128874
		Kelch_1	469..514	CDD:279660
		KELCH repeat	470..514	CDD:276965
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
bath-38	NP_496172.1	MATH	79..205	CDD:295307
		BTB	228..322	CDD:279045	26/95 (27%)
		BTB	229..322	CDD:197585	25/94 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000