DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and sdz-28

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_494192.1	Gene:	sdz-28 / 173569	WormBaseID:	WBGene00020073	Length:	326	Species:	Caenorhabditis elegans

Alignment Length:	168	Identity:	33/168 - (19%)
Similarity:	64/168 - (38%)	Gaps:	44/168 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SQVEDQYFVYKHDKLFGESFPLF--------------------------------KEIRRMGK-- 37
            |:|..:.|.:|.:|..|..:..|                                |.:|...|
Worm    81 SKVSSEIFKHKFEKNEGWGYFKFISWDTLTNDYLIDDCIIVEITVKITKMTGIPKKVLRSFDKSA 145

  Fly    38 --LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKE-SAIEPSALESLINYV 99
              ..||.|:|..:.|...:..||:...||.|:.   :.:..:.|:|::: |:::   .::|:..:
Worm   146 EEFSDVVLEVGGKKFYVLKKFLASHSTYFNALL---LGKPEMSEVTIQDTSSVD---FQNLLEVL 204

  Fly   100 YSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISR 137
            | |:..||...:..::..|....:......|..|||.:
Worm   205 Y-GEPAIDEDTIDGILTLAHKFTMPLPIQKCEEFLIEK 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	25/142 (18%)
		PHA03098	36..510	CDD:222983	24/107 (22%)
		BACK	143..245	CDD:285009
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965
		Kelch	340..386	CDD:128874
		KELCH repeat	376..417	CDD:276965
		Kelch	387..433	CDD:128874
		KELCH repeat	423..466	CDD:276965
		Kelch	435..480	CDD:128874
		Kelch_1	469..514	CDD:279660
		KELCH repeat	470..514	CDD:276965
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
sdz-28	NP_494192.1	MATH	14..127	CDD:279285	7/45 (16%)
		BTB	146..239	CDD:279045	21/99 (21%)
		BTB	150..242	CDD:197585	23/99 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000