DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and bath-47

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_494006.2	Gene:	bath-47 / 173532	WormBaseID:	WBGene00006464	Length:	706	Species:	Caenorhabditis elegans

Alignment Length:	270	Identity:	60/270 - (22%)
Similarity:	97/270 - (35%)	Gaps:	62/270 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLIN 97
            :.|.|..||.|.|:.:.|...|.:|:....||.::|   ..:|..:|..:  |.:||...:..:.
Worm    10 KSMEKYTDVVLVVKQERFYVSRAILSEHCTYFQSLF---CGDSNYQEHII--SDVEPQDFQKFLE 69

  Fly    98 YVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLIS-------------------RFHPHNV 143
            .|: |:..|....||.::..|.......|...|..|||:                   ....|..
Worm    70 VVH-GEPAIFEATVQKILPLAQKFGSKTVLQKCERFLITISTVRLSTKWNLAKQYGLDELQAHCK 133

  Fly   144 LGIRTFADSMICR-------QLIDAADKYI-DQNFAKVSQSEEFLALDCEQLLELMRRDELNVRT 200
            |..:|   :.|.|       :.:..:||:| |.:|.||    :.||             |.::|.
Worm   134 LEFKT---AQIVRKNPQPEPKSLAYSDKFIFDHSFEKV----DGLA-------------EGDMRR 178

  Fly   201 EEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREE--LIRSSHQCRDLLDEA 263
            .:.|......|..|...|...|      .|.|........:|...|.:  :..::....||:.:.
Worm   179 SQPITHLDFTWTIYITRKNQHL------RVSLCCGKAHLTSDWTVRADFKMTLTAKGSPDLVSDT 237

  Fly   264 KD-FHLMPER 272
            |. |||..|:
Worm   238 KGFFHLDSEK 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	26/101 (26%)
		PHA03098	36..510	CDD:222983	59/267 (22%)
		BACK	143..245	CDD:285009	23/109 (21%)
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965
		Kelch	340..386	CDD:128874
		KELCH repeat	376..417	CDD:276965
		Kelch	387..433	CDD:128874
		KELCH repeat	423..466	CDD:276965
		Kelch	435..480	CDD:128874
		Kelch_1	469..514	CDD:279660
		KELCH repeat	470..514	CDD:276965
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
bath-47	NP_494006.2	BTB	8..106	CDD:279045	26/101 (26%)
		BTB	17..109	CDD:197585	26/97 (27%)
		MATH	171..280	CDD:295307	20/96 (21%)
		MATH	455..552	CDD:295307
		BTB	563..670	CDD:279045
		BTB	577..673	CDD:197585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910