Protein Alignment KLHL18 and kel-20

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_491322.2
• Gene: kel-20 / 172012
• WormBaseID: WBGene00020030
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 585
• Identity: 228/585 - (38%)
• Similarity: 338/585 - (57%)
• Gaps: 15/585 - (2%)

  Fly     1 MDLSDNSQVEDQYF-------VYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLA 58
            |||...|......|       .||:.............::....||||||....:..:||||||:
 Worm    11 MDLPSTSHDSADMFESRKPQSKYKNSHFANSVLQQLGGLKNRDVLCDVTLICGWKRINAHRVVLS 75

  Fly    59 ATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQL 123
            |..|||.:|||:.|||..::||.|:|  |||..||:||.:.|:|.:.||:.|||:::..|..||:
 Worm    76 ACSPYFLSMFTSQMAECYMREINMEE--IEPPTLEALIEFCYTGAIAIDDSNVQDILPAACLLQI 138

  Fly   124 SNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLL 188
            ..|:.||..:|..:..|.|.||||.|||:..|::|:.:||::..:||::|...|||..|..|.|.
 Worm   139 HEVQTACCDYLKKQLDPSNCLGIRAFADTHSCKELLSSADEFALKNFSRVIGKEEFQMLTVESLT 203

  Fly   189 ELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSS 253
            .:::.|:||..:||::|.|.::||::...||......:|:.|||||.:|:||...|:.|.|::|.
 Worm   204 TIIKSDKLNAASEELVFSAVIQWVRHDISKRKTHLSMLLSHVRLPLCTPKFLVSVVSEEILVKSD 268

  Fly   254 HQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLT-- 316
            ...|||:||||::.|:|..|..:|..||:.|.....:..:|||||..| |::::::|..||:.
 Worm   269 PASRDLVDEAKNYLLLPVERPNMQGPRTKPRKPLQGSEVLYAVGGWCS-GDAIASIERLDPMKGG 332

  Fly   317 KKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCA--MLCKRSAV 379
            ..||....|...|..||||||...|||.||.:|...|:::|.|||..|:||...|  ..| |::|
 Worm   333 TTWKCVAPMGKRRCGVGVAVLENLLYAVGGHDGQSYLNSIERYDPMTNQWSSDVAPTATC-RTSV 396

  Fly   380 GVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGL 444
            ||||.:..:|..||.||.:.|:.||.|.|:.|.|..||.|...|....|:.:||.:||:||.:|.
 Worm   397 GVAAFNGSLYAVGGQDGESCLDVVEKYDPRKNEWAKVASMGTRRLGVSVSVVNGCIYAVGGSNGP 461

  Fly   445 SIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKL 509
            :..::|||||.....|.::.|||.:|..||.|..:|.||..||....:.|.:.|.|..:.|.|:.
 Worm   462 APLNTVERYDPRVGKWEEVRPMLTKRKHLGTAVYDGYIYAVGGRDTTTELNTAERYSVERDEWQP 526

  Fly   510 VTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            |..|:.:||.|.:|....||:|:||:||::.|.:||::|.:|::|.....|.....|.|.||:|:
 Worm   527 VVAMSNRRSGVGVAVVGEKLYAVGGFDGQTYLKSVEIFDKDTNRWKTHSQMFYRRLGGGVGVVRV 591

  Fly   575  574
             Worm   592  591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	47/116 (41%)
		PHA03098	36..510	CDD:222983	196/477 (41%)
		KELCH repeat	329..372	CDD:276965	22/44 (50%)
		KELCH repeat	376..417	CDD:276965	18/40 (45%)
		KELCH repeat	423..466	CDD:276965	15/42 (36%)
		KELCH repeat	470..514	CDD:276965	15/43 (35%)
		Kelch_1	517..560	CDD:396078	17/42 (40%)
		KELCH repeat	517..560	CDD:276965	17/42 (40%)
kel-20	NP_491322.2	PHA03098	56..572	CDD:222983	213/519 (41%)
		KELCH repeat	345..389	CDD:276965	22/43 (51%)
		KELCH repeat	393..437	CDD:276965	20/43 (47%)
		KELCH repeat	440..485	CDD:276965	17/44 (39%)
		KELCH repeat	487..531	CDD:276965	15/43 (35%)
		KELCH repeat	534..577	CDD:276965	17/42 (40%)