DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and Ipp

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_032415.2	Gene:	Ipp / 16351	MGIID:	96581	Length:	584	Species:	Mus musculus

Alignment Length:	609	Identity:	190/609 - (31%)
Similarity:	288/609 - (47%)	Gaps:	82/609 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKL------CDVTLKVEDQTFSAHRVVLAATIP 62
            :|||...|     ||.:|.         :.:|.|:      |||.|:|..:||..||:||||:.|
Mouse    10 ADNSFSSD-----KHAQLI---------LAQMNKMRSGQHFCDVQLQVGKETFQVHRLVLAASSP 60

  Fly    63 YFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVR 127
            ||.|:||..|.||. |:: ::...:|....:.|::::|:|.|.|...|||.|:|.|..|||:.|.
Mouse    61 YFAALFTGGMKESS-KDV-VQILGVEAGIFQLLLDFIYTGVVNIAVTNVQELIVAADMLQLTEVV 123

  Fly   128 DACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMR 192
            :.|..||..:..|.|.:|:..|::.:.|..|::..:.||..:|.:|...||||.|..:||::::|
Mouse   124 NLCCDFLKGQIDPQNCIGLFQFSEQIACHDLLEFTENYIHVHFLEVHTGEEFLGLTKDQLIKILR 188

  Fly   193 RDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCR 257
            .:||::..|..:|.|.|:|:.....||.:...:||..||.|||..|.|.
Mouse   189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPVRFPLLPSQRLL---------------- 237

  Fly   258 DLLDEAKDFHLMPERRGLLQSF---------------------RTRQRSGEFFTGQIYAVGGLA- 300
            ..::...||:|....:.||:.:                     |.|:::.::    :|||||..
Mouse   238 KYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKY----LYAVGGYTR 298

  Fly   301 ------STGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVY 359
                  |...::|.||.:|..::.|.....:...|..:||||:.|.:||.||...:......|.|
Mouse   299 LQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVVGGMVYAIGGEKDSMIFDCTECY 363

  Fly   360 DPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRS 424
            ||...:|:...:|...|..:||......||..||:.|....||:|.:.|..|.|:.|..|...|.
Mouse   364 DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGSMAVSRY 428

  Fly   425 AGGVTQLNGYVYALGG--HDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGG 487
            ..|..::.|.:||:||  ::||.: .|.|.||.....|..:.||..||..||||.||..||..||
Mouse   429 YFGCCEMQGLIYAVGGISNEGLEL-RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGG 492

  Fly   488 YC-GNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGG------YDGESNLSTVE 545
            :. ....|.:||.|..:.:.|..|..|...|:.:......|.|:..||      :.....|.:||
Mouse   493 WNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCAVTVNGLLYVSGGRSSSHDFLAPGTLDSVE 557

  Fly   546 VYDPETDKWTFMPPMCAH--SGGV 567
            ||:|.:|.||.:..|...  .|||
Mouse   558 VYNPHSDTWTEIGNMITSRCEGGV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	43/111 (39%)
		PHA03098	36..510	CDD:222983	162/510 (32%)
		BACK	143..245	CDD:285009	34/101 (34%)
		Kelch	292..339	CDD:128874	16/53 (30%)
		KELCH repeat	329..372	CDD:276965	15/42 (36%)
		Kelch	340..386	CDD:128874	13/45 (29%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		Kelch	387..433	CDD:128874	15/45 (33%)
		KELCH repeat	423..466	CDD:276965	14/44 (32%)
		Kelch	435..480	CDD:128874	20/46 (43%)
		Kelch_1	469..514	CDD:279660	18/45 (40%)
		KELCH repeat	470..514	CDD:276965	17/44 (39%)
		Kelch_1	517..560	CDD:279660	14/48 (29%)
		KELCH repeat	517..560	CDD:276965	14/48 (29%)
Ipp	NP_032415.2	BTB	27..131	CDD:279045	43/105 (41%)
		PHA03098	34..575	CDD:222983	178/563 (32%)
		BACK	139..241	CDD:285009	34/117 (29%)
		Kelch	290..343	CDD:128874	16/52 (31%)
		Kelch 1	296..343		11/46 (24%)
		KELCH repeat	333..376	CDD:276965	15/42 (36%)
		Kelch 2	344..390		13/45 (29%)
		Kelch	345..390	CDD:128874	13/44 (30%)
		KELCH repeat	380..424	CDD:276965	15/43 (35%)
		Kelch 3	391..437		15/45 (33%)
		Kelch	392..437	CDD:128874	15/44 (34%)
		KELCH repeat	427..473	CDD:276965	16/46 (35%)
		Kelch	438..485	CDD:128874	20/47 (43%)
		Kelch 4	439..485		20/46 (43%)
		KELCH repeat	475..520	CDD:276965	17/44 (39%)
		Kelch	486..533	CDD:128874	12/46 (26%)
		Kelch 5	487..533		12/45 (27%)
		KELCH repeat	523..574	CDD:276965	15/50 (30%)
		Kelch	534..584	CDD:128874	16/48 (33%)
		Kelch 6	535..583		16/47 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820