Protein Alignment KLHL18 and LOC1281663

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_061497908.1
• Gene: LOC1281663 / 1281663
• VectorBaseID: AGAMI1_004119
• Length: 675
• Species: Anopheles gambiae
• Alignment Length: 589
• Identity: 226/589 - (38%)
• Similarity: 323/589 - (54%)
• Gaps: 41/589 - (6%)

  Fly     6 NSQV-EDQYFVYK-HDKLFGESFPLFKEIRRM------GKLCDVTL--KVEDQTFSAHRVVLAAT 60
            ||.| :|::|..: |..:.         ::||      .|||||.|  .|:.:...|||:||:|:
Mosquito    34 NSSVSQDEFFRCRDHSDVV---------LKRMQDYLQSEKLCDVVLIAGVDGRRIPAHRLVLSAS 89

  Fly    61 IPYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSN 125
            ..||.||||..:.||:.:|||::|  :...||.|||.|.|:|.:.|....|:.|:..|..||||.
Mosquito    90 SAYFSAMFTGQLRESQQEEITLQE--VSGDALNSLIQYCYTGAIEIREDTVETLLATACLLQLST 152

  Fly   126 VRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLEL 190
            :..||.:||..:.||.|.||...||:...|..|:..|..|..|:|.:|.:::||..||..||..|
Mosquito   153 IVGACCNFLARQLHPSNCLGFSLFAEQQGCTALLKLATAYTCQHFQQVWKNQEFFMLDAAQLANL 217

  Fly   191 MRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQ 255
            :|.|:|||..|:.:|.|.|.|::|..:.|....|::||.::||||.|.|:.|.|  |.|...:::
Mosquito   218 LRSDDLNVPNEQEVFHALMAWIQYDAEGRKRHIPELLALIKLPLLQPSFIVDHV--EALCGGANE 280

  Fly   256 CRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWK 320
            |:.|:.||..:||:|.||.|:.:.|||.|....  |::.||||:.....::| :|.|||...||.
Mosquito   281 CQQLVMEAFKWHLIPGRRSLISTSRTRPRKSTM--GRLLAVGGMDGHKGAIS-IESYDPRLDKWT 342

  Fly   321 MGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGC-AMLCKRSAVGVAAL 384
            :.:.|...|.:.|||||:.||...||.:|.:.|:||:.:|.....||... .|...|..:|||.|
Mosquito   343 LLKNMPTRRLQFGVAVLDDKLIIVGGRDGLKTLNTVDSFDLNTMCWSTLVPPMGTPRHGLGVAFL 407

  Fly   385 DDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDS 449
            :..:|..||:||.:.|||||.:.|.:.||..||.|...||..||..|.|.:|.:||.||.....:
Mosquito   408 EGPLYAVGGHDGWSYLNTVERWDPSARTWSYVAPMSAMRSTAGVAVLGGRLYVIGGRDGSVCHRT 472

  Fly   450 VERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGY---------CGNSFLRSVECYDPQTD 505
            ||.||...:.|...:||..||..:||..|||.:|..||:         |...   :||.|||.||
Mosquito   473 VECYDPHTNKWTLRAPMNQRRGCVGVGVLNGFLYALGGHDCPPSNPAVCRTD---TVERYDPTTD 534

  Fly   506 TWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAG 570
            ||.|:..::..|..:.::.....|.|:|||||...|..||.||.||::||.:.|:  :....||.
Mosquito   535 TWTLIASLSVGRDAIGVSVLGDWLVALGGYDGIQYLKIVEQYDAETNEWTPIAPV--NYSRAGAC 597

  Fly   571 VIRI 574
            |:.|
Mosquito   598 VVAI 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	47/124 (38%)
		PHA03098	36..510	CDD:222983	195/485 (40%)
		KELCH repeat	329..372	CDD:276965	17/43 (40%)
		KELCH repeat	376..417	CDD:276965	18/40 (45%)
		KELCH repeat	423..466	CDD:276965	16/42 (38%)
		KELCH repeat	470..514	CDD:276965	20/52 (38%)
		Kelch_1	517..560	CDD:396078	17/42 (40%)
		KELCH repeat	517..560	CDD:276965	17/42 (40%)
LOC1281663	XP_061497908.1	None