Protein Alignment KLHL18 and LOC1279018

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_061518219.1
• Gene: LOC1279018 / 1279018
• VectorBaseID: AGAMI1_012011
• Length: 621
• Species: Anopheles gambiae
• Alignment Length: 574
• Identity: 223/574 - (38%)
• Similarity: 331/574 - (57%)
• Gaps: 6/574 - (1%)

  Fly     2 DLSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRM---GKLCDVTLKVEDQTFSAHRVVLAATIPY 63
            |||..:...|......|.:..|.....|..|.||   .:||||||:|..:|.:||:|:||:..||
Mosquito    37 DLSPPNMSNDDILPQAHHQNPGHCIASFSAINRMRQNAQLCDVTLEVGGETINAHKVILASVSPY 101

  Fly    64 FYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRD 128
            |||||.::|.|.....:|:.:  |:||:|:.||.|.|||::.|...|||.|:..:|.||:.:||:
Mosquito   102 FYAMFNDDMLERNCDVVTLHD--IDPSSLKQLIEYAYSGEITITEDNVQVLLPASSLLQIQSVRE 164

  Fly   129 ACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRR 193
            ||..||:.:.||.|.||||:|||:..|::|...:.:|..|||.:|..:||||.|...::.:|:..
Mosquito   165 ACCKFLLRQLHPSNCLGIRSFADAHSCKELHSRSHRYALQNFQQVVGTEEFLLLGFNEVQDLISN 229

  Fly   194 DELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRD 258
            .:||:.:||.:|.|.:.|||:...:|.:...::::.|||||:|.:||.:.|..|.|:|....|::
Mosquito   230 SQLNICSEEKVFMAVLNWVKHDLSERKKHISELMSHVRLPLVSREFLMNCVETEALVREESHCKE 294

  Fly   259 LLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGE 323
            ||.||..:||:||:|..|.|.||.:|..|.....|:|||| .|.....:..|.|:|.|..|....
Mosquito   295 LLLEAMKYHLLPEQRSSLVSQRTLERRPEGMRSYIFAVGG-GSLFAIHNECECYNPKTNAWMTIS 358

  Fly   324 QMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCI 388
            .|...|||.||..|...||..||::|...|:|.|.|:|..|:|:....|..|||.:|..|.|..:
Mosquito   359 PMISRRSRAGVTSLRKLLYVVGGYDGENDLATAECYNPLTNEWTNITPMGTKRSCLGTCAFDGLL 423

  Fly   389 YVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERY 453
            ||||||||.:.|::||.|.|.:..|.:...|...|....|..|:..:|:|||.|..:...||||:
Mosquito   424 YVCGGYDGASCLSSVERYDPLTGVWTSCPAMSTRRRYCRVAVLDNCIYSLGGFDSSNYQSSVERF 488

  Fly   454 DQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRS 518
            |.....|..:..|.:||...|||.|:|.:|..||..|...:::.|.::.:|:.|:.::.|:.:||
Mosquito   489 DPRVGSWSSVPSMTSRRSSCGVAALDGYLYCIGGSDGTMCMQTGERFNLRTNAWEPISAMHSRRS 553

  Fly   519 RVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVI 572
            ...:....|.|:|:||.||.|:|::||.|||:.:|||.:..|......:||.|:
Mosquito   554 THEVVEANGFLYALGGNDGSSSLNSVERYDPKVNKWTIVTSMLTRRSSIGASVL 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	52/119 (44%)
		PHA03098	36..510	CDD:222983	189/473 (40%)
		KELCH repeat	329..372	CDD:276965	18/42 (43%)
		KELCH repeat	376..417	CDD:276965	19/40 (48%)
		KELCH repeat	423..466	CDD:276965	14/42 (33%)
		KELCH repeat	470..514	CDD:276965	13/43 (30%)
		Kelch_1	517..560	CDD:396078	19/42 (45%)
		KELCH repeat	517..560	CDD:276965	19/42 (45%)
LOC1279018	XP_061518219.1	None