Protein Alignment KLHL18 and klhl10

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_308125.6
• Gene: klhl10 / 1269468
• VectorBaseID: AGAMI1_002870
• Length: 642
• Species: Anopheles gambiae
• Alignment Length: 541
• Identity: 163/541 - (30%)
• Similarity: 261/541 - (48%)
• Gaps: 27/541 - (4%)

  Fly    31 EIRRMGKLCDVTLKVED--QTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALE 93
            ::|....|||.::.:.|  ..|..|||::.:...||..:||.::...:..   ::...|..|.:|
Mosquito    45 DMRLSETLCDASIVLPDNGHEFRIHRVIVGSCSEYFRILFTTSVPSEKYH---VEIPGIPGSIME 106

  Fly    94 SLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQL 158
            .:|.|.|..:..:....|.::...|.||.:..:.:.|:.:::.|....|.:.|..|......:.|
Mosquito   107 QIIRYAYLRECELTEDTVFDVYAAADFLLMYCLTEHCSVYILDRLRLDNCVTIMLFGRQRASKTL 171

  Fly   159 IDAADKYIDQNFAKVSQS----EEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKR 219
            .:.|..:|.:||..::|:    .|.|.|:.:.:.:|:..|.||||.|:..:|..::|:.:...||
Mosquito   172 YEKARMFILKNFPLLAQTATSENELLQLEVDDVCQLLADDMLNVREEDTAWEFVLRWIDHDPTKR 236

  Fly   220 SELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDF---------HLMPERRGL 275
            .:...:::..||..||:.::..|:|...:.:.:|...:.|:.||..|         ..|.|.:
Mosquito   237 GKHIHRLMKTVRFGLLNTEYFLDKVKENQYVLASEDTKPLVIEALTFLYDLEMISTKAMKEMK-- 299

  Fly   276 LQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKW-KM-GEQMSMMRSRVGVAVLN 338
            ..:..|.:...|.    |:.|||... |:|.|.:|.||....:| |: .|..:..|:..|.|.:.
Mosquito   300 TPAIATPRLPHEV----IFTVGGWGE-GQSQSIIETYDTRADRWIKIPTEDPAGPRAYYGAAYIG 359

  Fly   339 GKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTV 403
            ..||..||::|.|..:|...:|..:..|.:...|.|||..|.|.|||..||..|||:|....|:|
Mosquito   360 RHLYFVGGYDGVEHFNTCRRFDMVQKDWQEIAPMHCKRCYVSVVALDGKIYAMGGYNGSNRHNSV 424

  Fly   404 EVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLN 468
            |.|.|::|.|..:|.|...||......|||.:|..||.:|....::.|.||...:.|..:.|||:
Mosquito   425 ERYDPQTNQWTLIAPMGSLRSDADACTLNGMIYIAGGFNGHECLNTAEMYDPHTNSWSPLPPMLH 489

  Fly   469 RRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIG 533
            ||..:..|.|...:||.||:.|...|.|.|.|||.|..|.....|..:||...|......|:|||
Mosquito   490 RRSGVSCAALGDSVYVVGGFNGLIRLNSCERYDPTTRRWTACKEMYHQRSNFGLEVIDDMLFAIG 554

  Fly   534 GYDGESNLSTVEVYDPETDKW 554
            ||||.|.::.||.|.|:.::|
Mosquito   555 GYDGVSAIAYVECYSPDANEW 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	24/107 (22%)
		PHA03098	36..510	CDD:222983	144/490 (29%)
		KELCH repeat	329..372	CDD:276965	12/42 (29%)
		KELCH repeat	376..417	CDD:276965	19/40 (48%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		KELCH repeat	470..514	CDD:276965	16/43 (37%)
		Kelch_1	517..560	CDD:396078	17/38 (45%)
		KELCH repeat	517..560	CDD:276965	17/38 (45%)
klhl10	XP_308125.6	None