DRSC/TRiP Functional Genomics Resources

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Protein Alignment KLHL18 and KLHL33

DIOPT Version :10

Sequence 1:NP_650143.1 Gene:KLHL18 / 41458 FlyBaseID:FBgn0037978 Length:575 Species:Drosophila melanogaster
Sequence 2:NP_001352719.1 Gene:KLHL33 / 123103 HGNCID:31952 Length:797 Species:Homo sapiens


Alignment Length:611 Identity:158/611 - (25%)
Similarity:239/611 - (39%) Gaps:127/611 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DLSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYA 66
            |:...||.|:          ..|:....:.:.|.|..||:.|:......|.||..||....:|.|
Human   210 DVKKPSQAEE----------LRENLRGIELLYREGVGCDLKLEAGGCQLSVHRAALACGSEFFGA 264

  Fly    67 MFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACA 131
            |..:.|.||:..|::::  .|....|..|:::.|||.||.....:......|...|.|:..|.|.
Human   265 MLLSGMRESQGTEVSLR--TISTQDLRLLVSFAYSGVVRARWPGLLRAAQAALQYQSSSCLDLCQ 327

  Fly   132 SFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDEL 196
            ..|.....|...|.:...|::....:|...|..|:..:...|:....|.:|....|.||:..|||
Human   328 KGLARGLSPARCLALFPMAEAPGLERLWSKARHYLLTHLPAVALCPAFPSLPAACLAELLDSDEL 392

  Fly   197 NVRTEEVIFEACMKW------------------VKYAEDKRSELFPQVLAAVRLPLLSPQFLADR 243
            :|:.|...|.|...|                  |::......|| .:|.||..||.|:|..|   
Human   393 HVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFGRMSTREL-RRVRAAGLLPPLTPDLL--- 453

  Fly   244 VAREELIRSSHQCRDLLDEA----KDFHLMPERR-------GLLQSFRTRQRSGEFFTGQIYAVG 297
                      ||   |:.||    ::....|:|.       ||......||.|...:..:.:..|
Human   454 ----------HQ---LMVEADVPGQERRREPDRALVVIGGDGLRPDMALRQPSRAVWWARAFRCG 505

  Fly   298 -GLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDP 361
             ||      |.|||        |                   |:|.|.                |
Human   506 VGL------VRTVE--------W-------------------GQLPAL----------------P 521

  Fly   362 RKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEV---YYPKSNTWKTVAQMMKYR 423
            ...::..|.|.|....          :|||||.|..:..||:..   :.|....|:.:|.:.:.|
Human   522 APGRFRHGAASLAGSE----------LYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQAR 576

  Fly   424 SAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRC-RLGVATLNGKIYVCGG 487
            |...:..|:|.:|||||.......||||.|:...:|| :.:|.|...| ....|.|.|::||.||
Human   577 SLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVW-RPAPALPAPCFAHAAAILEGQLYVSGG 640

  Fly   488 YCGNS--FLRSVECYDPQTD-TWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDP 549
             ||.:  :|.|:..|||:.: ....::||...|:...:||..|:|:..||.....:|.:.|.|:.
Human   641 -CGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYEL 704

  Fly   550 ETDKWTFMPPMCAHSGGVGAGVIRIE 575
            .||.||.:.|:.:...|..:.|::.|
Human   705 RTDSWTHLAPLPSPHVGAASAVLQGE 730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLHL18NP_650143.1 BTB_POZ_KLHL18 20..137 CDD:349556 32/116 (28%)
PHA03098 36..510 CDD:222983 132/510 (26%)
KELCH repeat 329..372 CDD:276965 5/42 (12%)
KELCH repeat 376..417 CDD:276965 10/43 (23%)
KELCH repeat 423..466 CDD:276965 16/42 (38%)
KELCH repeat 470..514 CDD:276965 16/47 (34%)
Kelch_1 517..560 CDD:396078 14/42 (33%)
KELCH repeat 517..560 CDD:276965 14/42 (33%)
KLHL33NP_001352719.1 BTB1_POZ_KLHL33 95..193 CDD:349571
BTB_POZ 224..341 CDD:453885 32/118 (27%)
BACK_KLHL33 334..408 CDD:350547 19/73 (26%)
NanM 512..774 CDD:442289 74/274 (27%)
KELCH repeat 525..574 CDD:276965 14/58 (24%)
KELCH repeat 576..619 CDD:276965 17/43 (40%)
KELCH repeat 623..669 CDD:276965 16/46 (35%)
KELCH repeat 672..717 CDD:276965 15/44 (34%)
KELCH repeat 719..765 CDD:276965 3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

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