DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and Keap1

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_006242653.1	Gene:	Keap1 / 117519	RGDID:	621619	Length:	624	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	204/568 - (35%)
Similarity:	310/568 - (54%)	Gaps:	50/568 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKV--ED---QTFSAHRVVLAATIPYFYA 66
            ||..::.|.|..:....::|.:..|:|...:||||||:|  ||   ..|.||:||||::.|.|.|
  Rat    45 SQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKA 109

  Fly    67 MFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACA 131
            ||||.:.|..::.::::  .|.|..:|.||.:.|:..:.:..:.|.::|.||...|:.:|..||:
  Rat   110 MFTNGLREQGMEVVSIE--GIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACS 172

  Fly   132 SFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDEL 196
            .||:.:..|.|.:||..||:.:.|.:|...|.:||..:|.:|::.|||..|...||..|:.||:|
  Rat   173 DFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDL 237

  Fly   197 NVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLD 261
            |||.|..:|.||:.||||...:|......:|.|||...|:|:||..::.:.|::::..:|:|.|.
  Rat   238 NVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLV 302

  Fly   262 EA-------KDFHLMPERR------------------GLLQSFRTRQRS---------------G 286
            :.       |....:|.|.                  ..|:::.....|               |
  Rat   303 QIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAG 367

  Fly   287 EFFTGQIYAVGGLASTGE---SVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFN 348
            ....|.:|||||..::.:   ..|.::.|:|:|.:|.....||:.|:|:||.|::|.:||.||.:
  Rat   368 CVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSH 432

  Fly   349 GTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTW 413
            |....|:||.|:|.:::|.....||.:|..||||.|:..:|..||:||...||:.|.|||:.|.|
  Rat   433 GCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEW 497

  Fly   414 KTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATL 478
            :.:..|...||..||..|:..:||.||:||....:||||||...:.|..::.|.:||..||:|..
  Rat   498 RMITPMNTIRSGAGVCVLHSCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVH 562

  Fly   479 NGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANM 526
            .|:|||.|||.|::||.|||||||.||||..||.:...||.|.:|..|
  Rat   563 QGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTM 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	41/110 (37%)
		PHA03098	36..510	CDD:222983	190/521 (36%)
		BACK	143..245	CDD:285009	41/101 (41%)
		Kelch	292..339	CDD:128874	17/49 (35%)
		KELCH repeat	329..372	CDD:276965	17/42 (40%)
		Kelch	340..386	CDD:128874	19/45 (42%)
		KELCH repeat	376..417	CDD:276965	19/40 (48%)
		Kelch	387..433	CDD:128874	19/45 (42%)
		KELCH repeat	423..466	CDD:276965	18/42 (43%)
		Kelch	435..480	CDD:128874	19/44 (43%)
		Kelch_1	469..514	CDD:279660	28/44 (64%)
		KELCH repeat	470..514	CDD:276965	27/43 (63%)
		Kelch_1	517..560	CDD:279660	5/10 (50%)
		KELCH repeat	517..560	CDD:276965	5/10 (50%)
Keap1	XP_006242653.1	BTB_POZ_KLHL19_KEAP1	56..180	CDD:349557	43/125 (34%)
		PHA03098	95..599	CDD:222983	182/505 (36%)
		KELCH repeat	362..409	CDD:276965	12/46 (26%)
		KELCH repeat	413..456	CDD:276965	17/42 (40%)
		KELCH repeat	460..503	CDD:276965	19/42 (45%)
		KELCH repeat	507..551	CDD:276965	18/43 (42%)
		KELCH repeat	554..597	CDD:276965	27/42 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820