DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and KLHL29

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_443152.1	Gene:	KLHL29 / 114818	HGNCID:	29404	Length:	875	Species:	Homo sapiens

Alignment Length:	565	Identity:	170/565 - (30%)
Similarity:	266/565 - (47%)	Gaps:	88/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GESFPLFKEI---RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAES---RIKEIT 81
            |....:.||:   ||.....|:.:.||.:.|..|:.|||:...||..:...::.:|   ..:::.
Human   310 GHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLE 374

  Fly    82 MKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGI 146
            :..|.::...||.|:.:||:|.:.||:.|.:.|:..||..|.......|.|||..:....|.||:
Human   375 LVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439

  Fly   147 RTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKW 211
            ...|::|.|.:|...|..:..|.|.:|:..||.|::..:..:..:..|.||.:.||:::|..:||
Human   440 LAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKW 504

  Fly   212 VKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLL 276
            :|.....|::...::||.||||.:.|.:|.:.|..||||:||..||||::|||.:|::|..|..:
Human   505 IKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEM 569

  Fly   277 QSFRTR-----------------------QRS------------------------GEFFT---- 290
            |:.|||                       |||                        .|||:
Human   570 QTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSA 634

  Fly   291 -GQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLS 354
             ..||..||:.| |.:::.|..|..|...|.:..:|::.|.|....|.:||:|..||......:.
Human   635 GDNIYLSGGMES-GVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVD 698

  Fly   355 TVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDC---IYVCGGY-DGVTSLNTVEVYYPKSNTWKT 415
            .||.||...|:| :..|.|.|  ||..||...|   |||.||. :...:...::.|.|::|||..
Human   699 HVERYDTITNQW-EAVAPLPK--AVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSF 760

  Fly   416 V-AQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVW------VKMSPMLNR-RCR 472
            : :.|:..:.|..|| |||:|:.|||           .|.:|..::      :|..|.:|. |..
Human   761 IESPMIDNKYAPAVT-LNGFVFILGG-----------AYARATTIYDPEKGNIKAGPNMNHSRQF 813

  Fly   473 LGVATLNGKIYVCGGYCGNS--FLRSVECYDPQTDTWKLVTPMNC 515
            .....|:||||..||...:.  .|.::|.|:|.|:||.|:..|.|
Human   814 CSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPC 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	32/111 (29%)
		PHA03098	36..510	CDD:222983	162/542 (30%)
		BACK	143..245	CDD:285009	31/101 (31%)
		Kelch	292..339	CDD:128874	14/46 (30%)
		KELCH repeat	329..372	CDD:276965	14/42 (33%)
		Kelch	340..386	CDD:128874	17/45 (38%)
		KELCH repeat	376..417	CDD:276965	15/45 (33%)
		Kelch	387..433	CDD:128874	16/50 (32%)
		KELCH repeat	423..466	CDD:276965	13/48 (27%)
		Kelch	435..480	CDD:128874	11/51 (22%)
		Kelch_1	469..514	CDD:279660	16/47 (34%)
		KELCH repeat	470..514	CDD:276965	16/45 (36%)
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
KLHL29	NP_443152.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..145
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..291
		BTB	319..427	CDD:279045	29/107 (27%)
		PHA03098	333..860	CDD:222983	164/542 (30%)
		BACK	436..537	CDD:285009	31/100 (31%)
		KELCH repeat	577..621	CDD:276965	3/43 (7%)
		Kelch 1	585..635		6/49 (12%)
		KELCH repeat	626..669	CDD:276965	13/43 (30%)
		Kelch 2	637..683		14/46 (30%)
		Kelch	638..683	CDD:128874	14/45 (31%)
		Kelch_1	672..717	CDD:279660	15/45 (33%)
		KELCH repeat	673..716	CDD:276965	15/43 (35%)
		Kelch 3	684..730		18/48 (38%)
		KELCH repeat	720..808	CDD:276965	29/99 (29%)
		Kelch_1	721..765	CDD:279660	13/43 (30%)
		Kelch 4	732..778		15/46 (33%)
		Kelch 5	779..821		11/52 (21%)
		KELCH repeat	811..857	CDD:276965	16/45 (36%)
		Kelch	822..870	CDD:128874	15/37 (41%)
		Kelch 6	822..870		15/37 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810