Protein Alignment KLHL18 and KLHL32

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_443136.2
• Gene: KLHL32 / 114792
• HGNCID: 21221
• Length: 620
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 152/572 - (26%)
• Similarity: 271/572 - (47%)
• Gaps: 48/572 - (8%)

  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLIN 97
            |..|.|||:||..|:|.|.||:.||||...||.|||:..|.||...|:.:  ..:....|:..:.
Human    36 RSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNL--HGVTSLGLKQALE 98

  Fly    98 YVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFAD----SMICRQL 158
            :.|:||:.::...:|:::...|.|||..:.:.|:.:||...:..|.|.:...||    :::.:.:
Human    99 FAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAV 163

  Fly   159 IDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELF 223
            ||...|::.:...  |:.||.|.|....|.|:::.|.|...:||.|::..::|:::  :...:..
Human   164 IDFLVKHLSELLK--SRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH--NCHYQYM 224

  Fly   224 PQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEF 288
            .::|..:|..|:....|........|:::|.....|::||.::|.....:.:.|:.||:.|   |
Human   225 DELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPR---F 286

  Fly   289 FTGQIYAVGGLASTGESVSTVEIYDPLTKK---------WKMGEQMSMMRSRVGVAVLNGKLYAF 344
            .:..:|.:||.......|..:..::|:.::         |.....|.:.||...|||:...|:..
Human   287 QSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVA 351

  Fly   345 GG--FNGTERLSTVEV---YDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS-LNTV 403
            ||  .:.:.|...|..   ||||.|.|::...|...|....:.|:::.:|..||.:.:.. |.||
Human   352 GGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTV 416

  Fly   404 EVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDS-VERYDQAEDVWVKMSPML 467
            |.|.||.|.|..|....:..|.......:|.::..||....:.:.: :..|:..::.|:..||||
Human   417 ERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPML 481

  Fly   468 NRRCRLGVATLNGKIYVCGG----YCGNSFL-RSVECYDPQTDTW-----KLVTPMNCKRSRVAL 522
            .||....:|.:..|:||.||    |..:..| |.::.|:..||.|     .|:|..|    ...:
Human   482 QRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQN----ESGV 542

  Fly   523 AANMGKLWAIGGYDGESN--LSTVEVYDPE---TDKWTFMPPMCAHSGGVGA 569
            |.:.|:::.:|||...:|  |:.::|.|..   .::..:.|.:...|.|:.|
Human   543 AVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAA 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	37/103 (36%)
		PHA03098	36..510	CDD:222983	135/503 (27%)
		KELCH repeat	329..372	CDD:276965	16/47 (34%)
		KELCH repeat	376..417	CDD:276965	14/41 (34%)
		KELCH repeat	423..466	CDD:276965	7/43 (16%)
		KELCH repeat	470..514	CDD:276965	16/53 (30%)
		Kelch_1	517..560	CDD:396078	10/47 (21%)
		KELCH repeat	517..560	CDD:276965	10/47 (21%)
KLHL32	NP_443136.2	BTB_POZ_KLHL32	14..146	CDD:349570	38/111 (34%)
		BACK_KLHL32_BKLHD5	139..236	CDD:350546	22/100 (22%)
		Kelch 1	290..346		12/55 (22%)
		Kelch	291..346	CDD:128874	12/54 (22%)
		NanM	324..595	CDD:442289	75/275 (27%)
		KELCH repeat	336..384	CDD:276965	16/47 (34%)
		Kelch 2	347..398		14/50 (28%)
		KELCH repeat	388..433	CDD:276965	15/44 (34%)
		Kelch 3	399..446		14/46 (30%)
		KELCH repeat	436..482	CDD:276965	9/45 (20%)
		Kelch 4	447..494		11/46 (24%)
		KELCH repeat	484..534	CDD:276965	14/49 (29%)
		Kelch 5	496..547		15/54 (28%)
		Kelch 6	549..599		11/46 (24%)